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CHEE 450 Design Project: Rotary Evaporator

CHEE 450 Design Project: Rotary Evaporator. Drew Payette Matt Schuster Dave Willis. Presentation Outline. Purpose within the Overall Process How Rotary Evaporators Work Design Considerations Purposed Unit and Operating Parameters Alternatives Questions.

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CHEE 450 Design Project: Rotary Evaporator

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  1. CHEE 450 Design Project:Rotary Evaporator Drew Payette Matt Schuster Dave Willis

  2. Presentation Outline • Purpose within the Overall Process • How Rotary Evaporators Work • Design Considerations • Purposed Unit and Operating Parameters • Alternatives • Questions

  3. Purpose within the Overall Process • Evaporation of large amounts of unwanted solvent within the process. Figure 1 - Position of rotary evaporator within the insulin production process.

  4. How Rotary Evaporators Work • Use of high vacuum system • Heating bath • Rotating flask causes centrifugal and frictional forces • Solvents move to condenser • Collection flask Figure 2 - Components of a standard rotary evaporator (Lennox)

  5. Design Considerations • SuperPro Data • Batch process • Overall flowrate of 50.43 L/hr • Required evaporation rate of 43.86 L/hr • Main solvent constituents: • Formic Acid (82.77 wt%) • Water for injection (15.03 wt%) • Evaporating flask size • Rate of evaporation of solvent • Operating temperature • Effect of degradation on insulin • Cost of unit

  6. Purposed Unit and Operating Parameters • 100 L Rotary Evaporator • Operating Conditions • Evaporating Flask initial volume is 50 L • Temperature of 40 oC • Evaporation rate is 11.5 L/hr • Four rotary evaporator running simultaneously • Batch time of 3.8 hours before switching flasks

  7. Alternatives • Centrifugal Evaporation • Gel filtration • Freeze drying

  8. Questions??

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