The University of Minnesota is an equal opportunity educator and employer.

1. Brain Barrier Research Center: A Multidisciplinary Approach to Advancing Brain Barriers Research William Elmquist, John Ohlfest, Lester Drewes, et al. University of Minnesota College of Pharmacy and Medical School • Targeted drug delivery to the CNS • Drug transport proteins • Pharmacokinetics Decisions limited by available data at specific sites input Mission output bolus IC, CED exchange neuronal and glial cell mem- branes The mission of the Brain Barriers Research Center (BBRC) is to improve therapy delivery and treatments of brain disordersby fostering interdisciplinary brain barrier research. extra- cellular fluid brain capillaries intracellular fluid IV plasma choroid plexus arachnoid membrane ependyma pia mater ICV, IT cerebrospinal fluid Compartmental model for solute exchange in the brain • MCT1 and GLUT1 transporter regulation • BBB molecular biology • Brain vasculogenesis The Brain Barriers Research Center (BBRC) is a distinctive, cutting edge University of Minnesota research group involving members in the College Goals • Basic Science to Clinical Practice • Experimental Models • Pharmacokinetics/ pharmacodynamics • High throughput screening/assay develop • In situ brain profusion techniques • In vitro to in vivo • MRI/MRS to microdialysis • Blood-brain transport quantification Expertise • Role of BBB transporters in Alzheimer's disease • BBB function in CNS disorders of Pharmacy and the Medical School in the Academic Health Center (Duluth and Twin Cities). Twenty-two faculty are involved in research ranging from genetic factors in hibernation to synthesis of neuroactive pharmaceutics. • Regulation of drug efflux transporters at the BBB • Improving therapies for CNS diseases University Collaborative Resources • Institute for Translational Neuroscience (www.itn.umn.edu) • Center for Translational Medicine (www.ahc.umn.edu/ctm) • Center for Magnetic Resonance Research (www.cmrr.umn.edu) • Institute for Therapeutics Discovery and Development • Epilepsy • Stroke • Brain tumor (glioblastoma, GBM) • Alzheimers Disease • CNS virus • Parkinson’s Disease • Glucose transporter deficiency syndrome Current Projects • Neurosurgery • Gliomas • Blood brain barrier modification The University of Minnesota is an equal opportunity educator and employer. BBRC Web Site: www.pharmacy.umn.edu/bbrc