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30/07/2012. Dr Habib Tareif, FRCSI. Peripheral Vascular Disease. Arterial : Chronic : Atherosclerotic, Small vessels, Vasculitis Acute : Embolic, Thrombotic"VenousNeuropathic. 2. 30/07/2012. Dr Habib Tareif, FRCSI. "Objectives of this problem" . To provide an outline of PVDDiscuss chroni
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1. 30/07/2012 Problem Solving session “PVD” “BLACK TOE” Dr. Habib Tareif, FRCSI
AGU Dr Habib Tareif, FRCSI 1
2. 30/07/2012 Dr Habib Tareif, FRCSI Peripheral Vascular Disease Arterial :
Chronic : Atherosclerotic, Small vessels, Vasculitis
Acute : Embolic, Thrombotic”
Venous
Neuropathic
2
3. 30/07/2012 Dr Habib Tareif, FRCSI ”Objectives of this problem” To provide an outline of PVD
Discuss chronic arterial disease
Aetiology
Presentations
Investigations
Management
Review acute arterial occlusion 3
4. 30/07/2012 History 65 y old patient presented with
Black discoloration of left 2nd & 3rd toes
He developed Painful left lower limb
Exercise induced and progressive
Marked pain after 10 meters in the last few weeks and rest pain for one week
Heavy smoker & has Type II DM
Past H/O acute AWMI 4 Dr Habib Tareif, FRCSI
5. 30/07/2012 History
Any Further Questions in his History Dr Habib Tareif, FRCSI 5
6. 30/07/2012 History Dr Habib Tareif, FRCSI 6 Angina
CVA/ TIA / Amaurosis fugax
Medications
Did he have any other surgery
7. 30/07/2012 Examination General condition is good
Pulse= 80/min & regular, BP= 160/100
Bilateral carotid bruit.
Systolic murmur grade 2/6 radiate to neck
No abdominal scars or bruit
7 Dr Habib Tareif, FRCSI
8. 30/07/2012 Assessment of PVDIschaemic limb Dr Habib Tareif, FRCSI 8
9. 30/07/2012 Lower Limb AssessmentInspection Chronic Ischemic changes
“Hair loss, shiny appearance & Trophic changes”
Dry gangrene distal ½ of 2nd & 3rd toes
Buerger’s critical angle 9 Dr Habib Tareif, FRCSI
10. 30/07/2012 Palpation Assessment of pulses Assess temperature
Oedema
Venous re-filling
Capillary circulation
10 Dr Habib Tareif, FRCSI
11. 30/07/2012 Palpation Assessment of pulses Pulses (Grades 1-4)
Pulse Fem Pop PT DP
Right 4 4 1 1
Left 3 0 0 0
11 Dr Habib Tareif, FRCSI
12. 30/07/2012 Discuss The arteries of the lower limb
The causes of black toe
Pathology “Atherosclerosis”
Pathogenesis of presentation
Influence of DM on development of PVD 12 Dr Habib Tareif, FRCSI
13. 30/07/2012 Management Admission.
Full history & physical examination.
Blood tests.
Non invasive investigations.
Invasive investigations.
Treatment. 13 Dr Habib Tareif, FRCSI
14. 30/07/2012 Treatment Medical treatment
Angiography and PCI
“Angioplasty and stents”
Surgical Options
“Fem-Pop Bypass, etc….”
Prognosis.
Life style modification. 14 Dr Habib Tareif, FRCSI
15. 30/07/2012 Peripheral vascular disease of the lower extremitiesDefinition “Decreased patency” of the arterial supply to the lower extremities leading to
Intermittent Claudication
Ischemic rest pain
potentially limb loss “Compromised” 15 Dr Habib Tareif, FRCSI
16. 30/07/2012 Etiology Atherosclerosis
Vasculitis
Burger's Disease (Thromboangiitis
Obliterans)
Extrinsic compression (neoplasm) 16 Dr Habib Tareif, FRCSI
17. 30/07/2012 Atherosclerosis Thickening and hardening of arteries
Some hardening is normal with age
Plaque may partially or totally block the blood's flow through an artery 17 Dr Habib Tareif, FRCSI
18. 30/07/2012 Atheroma Plaques can form from damage to arterial walls by
Increase levels of cholesterol and triglyceride in the blood
Increase in blood pressure
Tobacco smoking
“Cellular debris will adhere to plaques (cholesterol etc.)
“Endothelium becomes thick and the diameter of the artery is reduced” 18 Dr Habib Tareif, FRCSI
19. 30/07/2012 Risk Factors Hypertension
Cigarette smokers
Diabetics
Hyperlipidaemia
Increased age
History of other atherosclerotic disease
(coronary artery disease or carotid stenosis) 19 Dr Habib Tareif, FRCSI
20. 30/07/2012 Pathophysiology “Narrowing of the arterial lumen leads to”
Decreased blood flow resulting in.
Decreased O2 supply leading to
Anaerobic metabolism
Increased Lactic Acid
Pain with increased muscle use 20 Dr Habib Tareif, FRCSI
21. 30/07/2012 Pathophysiology
As decreased blood flow or compromised integrity continues, tissues can become ischemic leading to:
Pain at rest
Poor wound healing
Painful ulceration
21 Dr Habib Tareif, FRCSI
22. 30/07/2012 Pathophysiology As disease progresses patients are sometimes
unable to ambulate and gangrene may set in
with eventual need for amputation 22 Dr Habib Tareif, FRCSI
23. 30/07/2012 Acute Complication of Atheroma
Two things that can happen where plaque occurs are:
Hemorrhage into the plaque
Plaque ruptures and a blood clot (thrombus)
forms on surface
(Affects large and medium-sized arteries) 23 Dr Habib Tareif, FRCSI
24. 30/07/2012 Consequence of arterial block
Heart attack = reduced blood supply to heart
Stroke = reduced blood supply to brain
Gangrene = reduced blood supply to arms and legs Dr Habib Tareif, FRCSI 24
25. 30/07/2012 Dr Habib Tareif, FRCSI Chronic Ischaemia Intermittent Claudication +/- Rest Pain
Cold Peripheries
Arterial Ulcers
Wet/dry gangrene 25
26. 30/07/2012 Dr Habib Tareif, FRCSI Claudication Definition: Muscle pain which appears during exercise when there is an inadequate arterial flow
Intermittent Claudication
Claudicato = to limp
26
27. 30/07/2012 Dr Habib Tareif, FRCSI Intermittent Claudication Claudication Distance:
The distance the patient is able to walk before onset of pain.
Must be recorded accurately 27
28. 30/07/2012 Clinical Presentation Claudication requires a sustained walk
cramping/burning muscular pain
localized to a muscle group (calf)
reproducible
relieved with rest
Distribution of pain may suggest anatomic
location of disease 28 Dr Habib Tareif, FRCSI
29. 30/07/2012 Dr Habib Tareif, FRCSI Intermittent Claudication
Differential Diagnosis
Nerve Root Compression
Arthropathy
Spinal Stenosis 29
30. 30/07/2012 Clinical Presentation
“Must differentiate Claudication from pseudoclaudication”
Character location is the same as cramp and tightness
Location of pain is the same
BUT
Claudication is Exercise induced.
The Distance to symptoms is reproducible
It is Relieved by Stop walking not by Change of position
No Symptoms with standing
Character and location is the same as cramp and tightness
30 Dr Habib Tareif, FRCSI
31. 30/07/2012 Intermittent Claudication 30% are Diabetics
Increased relative risk of death x3
50%-heart disease
15%-stroke
32. 30/07/2012 Dr Habib Tareif, FRCSI Rest Pain Pain caused by critical Ischaemia
worse at night
May be present throughout the day and night
Continuous, aching & severe
Located in toes and forefoot.
(Patient hangs the leg over the side of the bed) 32
33. 30/07/2012 Physical Examination
Skin
Thin, brittle, shiny with thick opaque toes
Often cool
No hair
Poor capillary refill 33 Dr Habib Tareif, FRCSI
34. 30/07/2012 PHYSICAL EXAMINATION
Pulse exam
Palpable vs. non-palpable
Audible by Doppler vs. not audible
Compare limbs
Pulse exam helps define level of disease
May also examine pulses after exercise 34 Dr Habib Tareif, FRCSI
35. 30/07/2012 Dr Habib Tareif, FRCSI INVESTIGATION OF PVD Assess risk factors:
Fasting lipids & glucose, HbA1c
Non-Invasive
Doppler Ankle/Brachial Index & Duplex
Invasive
CT Angiogaphy/ MRI
Angiography 35
36. 30/07/2012 Dr Habib Tareif, FRCSI 36
37. 30/07/2012 Dr Habib Tareif, FRCSI Digital Pressures: useful in Diabetes Mellitus. Why? 37
38. 30/07/2012 Duplex Ultrasound Advantages
Noninvasive
Fast/cheap
Few complications
Disadvantages
Dependent on ultrasonographers ability
Poor visualization below the knee 38 Dr Habib Tareif, FRCSI
39. 30/07/2012 Arteriography Advantages
Gold standard for demonstrating anatomy of
disease
Provides therapeutic opportunities: eg.PTA
Disadvantages
Invasive
risk of hemorrhage, aneurysm, infection
Contrast load is nephrotoxic 39 Dr Habib Tareif, FRCSI
40. 30/07/2012 CT ANGIOGRAPHY & Magnetic Resonance
Advantages
Good resolution
Allows visualization of surrounding structures
Noninvasive with few complications
Disadvantages
No intervension
Efficacy has not been completely demonstrated
Cost/availability 40 Dr Habib Tareif, FRCSI
41. 30/07/2012 Claudication Treatment
STOP SMOKING
Exercise program
Control diabetes, lower cholesterol
Pentoxyphylline
Cilostazole
“75% improve with non-operative management” 41 Dr Habib Tareif, FRCSI
42. 30/07/2012 Treatment of critical ischemia“Ischemic rest pain/ulcer/gangrene”
Must first determine how patient uses limb
Angioplasty vs. Surgery
“Gangrene or blackened toes require amputation but revascularization may preserve level and use of limb” 42 Dr Habib Tareif, FRCSI
43. 30/07/2012 Dr Habib Tareif, FRCSI ARTERIAL ULCERS PAINFUL!
PUNCHED OUT ”NOT SUPERFICIAL LIKE VENOUS”
SURROUNDING EVIDENCE OF ARTERIAL DISEASE
pale,
loss of hair,
decreased capillary refill,
decreased or absence of pulses
43
44. 30/07/2012 Dr Habib Tareif, FRCSI Burger's Disease (Thromboangiitis Obliterans) Clinical Features
Males <45 years
Upper and lower limb involvement
Heavy smokers
Angiogram
Normal proximal arteries
Distal occlusions 44
45. 30/07/2012 Dr Habib Tareif, FRCSI The Diabetic Foot Pathophysiology
Ischaemia (Microangiopathy/Macroangiopathy)
Neuropathy
Sepsis 45
46. 30/07/2012 Dr Habib Tareif, FRCSI Chronic IschaemiaConservative Management Increasing exercise tolerance
Pharmacotherapy's: Decrease rate of progression i.e.; Anti Platelet agents & Statins.
STOP SMOKING!
ACE I {esp. in Diabetics }
Avoidance of minor trauma esp. in those with neuropathy / PVD => Lower amputation rates
46
47. 30/07/2012 Dr Habib Tareif, FRCSI Surgical Management Endovascular options: to increase inflow if suitable for femoral angioplasty or stenting
Surgical bypass of diseased segment using vein or prosthetic graft
If un-reconstructable: Try Prostacyclin infusion (Iloprost)
Last option is amputation 47
48. 30/07/2012 Dr Habib Tareif, FRCSI Amputations 50% of major amputations die within 3 yrs. Why?
Post Amputation:
39 %totally wheelchair bound at 5 yrs
5% wheelchair free
56% undergo limb fitting
85% of these are walking at 1 year
30 % are walking at 5 years
Amputation Levels as distal as possible in interest of mobility
The key to social reintegration
48
49. 30/07/2012 Dr Habib Tareif, FRCSI Arterial Ulcer 49
50. 30/07/2012 Dr Habib Tareif, FRCSI Dry Gangrene: No infection 50
51. 30/07/2012 Dr Habib Tareif, FRCSI Wet Gangrene: Infected! 51
52. 30/07/2012 Dr Habib Tareif, FRCSI Femoral Angiography 52
53. 30/07/2012 Dr Habib Tareif, FRCSI Neuropathic Ulcers 53
54. 30/07/2012 Dr Habib Tareif, FRCSI NEUROPATHIC ULCER 54
55. 30/07/2012 Acute Ischemia presentation Sudden Severe Agonizing Pain
Parasthesia
Discoloration
Loss of movement
Cold Limb 55 Dr Habib Tareif, FRCSI
56. 30/07/2012 Dr Habib Tareif, FRCSI Acute Ischaemia Clinical Features
Pain
Pallor
Parasthesia.
Paralysis
Pulselessness
Perishing Cold
Pistol Shot onset 56
57. 30/07/2012 Dr Habib Tareif, FRCSI Acute Limb Ischaemia
Embolus
Thrombus
Trauma 57
58. 30/07/2012 Dr Habib Tareif, FRCSI Acute Limb Ischaemia Source of Emboli
Heart - 90%
- Arrhythmias
- Valvular heart disease
- Prosthetic heart valves
- Mural thrombus post MI
- Ventricular aneurysm 58
59. 30/07/2012 Dr Habib Tareif, FRCSI Acute Limb Ischaemia Source of Emboli
Great Vessels (9%)
Atherosclerotic aorta
Aortic aneurysm
Popliteal artery aneurysm
Other (1%)
Paradoxical
59
60. 30/07/2012 Dr Habib Tareif, FRCSI Acute Limb Ischaemia Thrombus
Thrombus on a pre-existing atherosclerotic lesion
Patient has history of intermittent Claudication 60
61. 30/07/2012 Acute Ischaemia Treatment Urgent Treatment, Heparin
Heparin
Investigations
Intervention
? Thrombolytic 61 Dr Habib Tareif, FRCSI
62. 30/07/2012 Dr Habib Tareif, FRCSI Acute Limb Ischaemia Vascular Trauma 62
63. 30/07/2012 Dr Habib Tareif, FRCSI 63
64. 30/07/2012 Dr Habib Tareif, FRCSI Trash Foot- Late Presentation 64
65. 30/07/2012 Dr Habib Tareif, FRCSI Summary Arterial Disease => acute vs. chronic
Venous Disease
Diabetes 65
66. 30/07/2012