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Influenza Research Database (IRD)

Influenza Research Database (IRD). 26 September 2011 Richard H. Scheuermann, Ph.D. Department of Pathology U.T. Southwestern Medical Center. History of IRD. APR2007. SEP2004. DEC2009. CEIRS Network. Influenza Virus. Orthomyxoviridae family Negative- strand RNA Segmented Enveloped.

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Influenza Research Database (IRD)

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  1. Influenza Research Database(IRD) 26 September 2011 Richard H. Scheuermann, Ph.D. Department of Pathology U.T. Southwestern Medical Center

  2. History of IRD APR2007 SEP2004 DEC2009

  3. CEIRS Network

  4. Influenza Virus Orthomyxoviridae family Negative-strand RNA Segmented Enveloped 8 RNA segments encode 11 proteins Classified based on serology of HA and NA

  5. Public Health Impact of Influenza • Seasonal flu epidemics occur yearly during the fall/ winter months and result in 3-5 million cases of severe illness worldwide. • More than 200,000 people are hospitalized each year with seasonal flu-related complications in the U.S. • Approximately 36,000 deaths occur due to seasonal flu each year in the U.S. • Populations at highest risk are children under age 2, adults age 65 and older, and groups with other co-morbidities. • Pandemics • 1918 Spanish flu (H1N1); 20 - 100 million deaths • 1957 Asian flu (H2N2); 1 - 1.5 million deaths • 1968 Hong Kong flu (H3N2); 750,000 - 1 million deaths • 2009 Swine origin (H1N1); > 16,000 deaths as of March 2010 Source: World Health Organization - http://www.who.int/mediacentre/factsheets/fs211/en/index.html

  6. IRD Overview www.fludb.org

  7. Data Summary

  8. Data Sources

  9. Search Access to Data www.fludb.org

  10. Data Types

  11. Analysis and Visualization www.fludb.org

  12. Analysis and Visualization Tools

  13. Workbench Access www.fludb.org

  14. Data Submission www.fludb.org

  15. Data Submission Page

  16. Data Integration

  17. 3D Structure Viewer

  18. Unique Community Data

  19. Surveillance Search

  20. Google Maps Display

  21. Unique IRD Data

  22. SFVT

  23. SF definition • SF can be defined for any region of interest because of structural or functional properties • Defined based on experimentation reported in the literature, 3D protein structures (PDB records), UniProt annotations and IEDB epitope records • Defined by the specific amino acid positions in the polypeptide chain • Manually curated and externally validated

  24. SF Counts

  25. NS1 Functional SFs

  26. SF Details

  27. VTs

  28. VT-specific Strain List

  29. IRD Summary • Funded by U.S. National Institute of Allergy and Infectious Diseases (NIAID) • Free and open access with no use restrictions • Developed by a team of research scientists, bioinformaticians and professional software developers • Comprehensive collection of public data • Novel derived data, novel analytical tools, unique functions • Integration – Integration – Integration • www.fludb.org

  30. Challenges and Future Directions • Inconsistent annotations • Competition with other influenza-focused resources • GISAID collaboration • Host systems biology and “omics” data

  31. U.T. Southwestern Richard Scheuermann (PI) Burke Squires JyothiNoronha Victoria Hunt ShubhadaGodbole Brett Pickett Yun Zhang MSSM Adolfo Garcia-Sastre Eric Bortz Gina Conenello Peter Palese Vecna Chris Larsen Al Ramsey LANL Catherine Macken Mira Dimitrijevic U.C. Davis Nicole Baumgarth Northrop Grumman Ed Klem Mike Atassi Kevin Biersack Jon Dietrich WenjieHua Wei Jen Sanjeev Kumar Xiaomei Li Zaigang Liu Jason Lucas Michelle Lu Bruce Quesenberry Barbara Rotchford Hongbo Su Bryan Walters JianjunWang Sam Zaremba LiweiZhou Acknowledgments • IRD SWG • Gillian Air, OMRF • Carol Cardona, Univ. Minnesota • Adolfo Garcia-Sastre, Mt Sinai • ElodieGhedin, Univ. Pittsburgh • Martha Nelson, Fogarty • Daniel Perez, Univ. Maryland • Gavin Smith, Duke Singapore • David Spiro, JCVI • Dave Stallknecht, Univ. Georgia • David Topham, Rochester • Richard Webby, St Jude • USDA • David Suarez • Sage Analytica • Robert Taylor • Lone Simonsen • CEIRS Centers N01AI40041

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