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Limsoon Wong Kent Ridge Digital Labs Singapore

Role of Bioinformatics in the Genomic Era. Limsoon Wong Kent Ridge Digital Labs Singapore. What are the Themes of Bioinformatics?. Bioinformatics = Data Mgmt + Knowledge Discovery Data Mgmt = Integration + Transformation + Cleansing Knowledge Discovery =

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Limsoon Wong Kent Ridge Digital Labs Singapore

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  1. Role of Bioinformatics in the Genomic Era Limsoon Wong Kent Ridge Digital Labs Singapore

  2. What are the Themes of Bioinformatics? Bioinformatics = Data Mgmt + Knowledge Discovery Data Mgmt = Integration + Transformation + Cleansing Knowledge Discovery = Statistics + Algorithms + Databases

  3. What are the Benefits of Bioinformatics? • To the patient: • Better drug, better treatment • To the pharma: • Save time, save cost, make more $ • To the scientist: • Better science

  4. Transcription Start Prediction

  5. Transcription Start Prediction Results

  6. Medical Record Analysis • Looking for patterns that are • valid • novel • useful • understandable

  7. Medical Record Analysis Results • DeEPs, the “emerging pattern’’ method • Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI benchmarks • Works for gene expressions • ALL vs AML: • DeEPS (1 gene) - 0/38 & 3/34 • Slonim (50 genes) - 2/38 & 5/34 • Colon: • DeEPS (35 genes) - 4/62 • Alon (1000 genes) - 6/62

  8. Genome-Enabled Fruits • A lot of genes & proteins that are • candidate diagnosis indicators • candidate prognosis indicators • candidate drug targets What’s Next?

  9. Evaluate & Choose the Better Candidates • Easier to access • Uncomplicated to modulate • Clear path to $ • Has experience To do that, you will need to have ….

  10. INTERACTIONS DISEASES PATENTS EXPRESSION RELATED MOLECULES MUTATIONS STRUCTURE A Molecular Connections Database consisting of...

  11. Thank You

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