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Ahn & Phillips Journal of Neuroscience 1999 Department of Psychology

Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat. Ahn & Phillips Journal of Neuroscience 1999 Department of Psychology University of British Columbia. “Big Picture” Questions. Why do we eat? Why do we stop eating?

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Ahn & Phillips Journal of Neuroscience 1999 Department of Psychology

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  1. Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat Ahn & Phillips Journal of Neuroscience 1999 Department of Psychology University of British Columbia

  2. “Big Picture” Questions • Why do we eat? Why do we stop eating? • Why do we prefer certain foods? • How do we learn what we prefer? • Why do we sometimes reject certain foods but in other circumstances we eat it? • How does our state of hunger affect what and how much we eat? • What regions of the brain are involved? • What neurotransmitters are involved?

  3. Background InformationPart 1: Sensory Specific Satiety • Phenomenon described in 1980’s by Rolls and colleagues • Now want to know the mechanism of SSS

  4. Background InformationPart 1: Sensory Specific Satiety • Rolls 1986 • Reported: Firing rates in neurons of orbitofrontal lobe of monkeys change in response to specific tastes and satiety signals • Concluded: This region of brain is involved is some aspect of SSS

  5. Background InformationPart 1: Sensory Specific Satiety • Rolls 1999 (book) • Many steps between the sensory processing of taste and the motivation to eat or stop eating • Orbitofrontal cortex is believed to be involved in motivation • Ahn & Phillips (this paper) • Predict that feeding behaviors will be correlated with changes in neuronal activity in the corresponding region of the rat brain [medial prefrontal cortex (mPFC)]

  6. Background InformationPart 2: The Role of Dopamine

  7. Microdialysis probe Source: www.chemistry.emory.edu/. ../microdialysis.htm

  8. Source: www.chemistry.emory.edu/. ../microdialysis.htm

  9. Source: http://utopia.utexas.edu/project/brainwaves/courses/neuro/images/NBA-VI-050123-001.gif

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