1 / 3

Work Package 6: Biomotors

13ns. 20ns. Objectives. Partners. PM. Midterm-Review Meeting. Molecular Machines- Design and Nano-Scale Handling of Biological Antetypes and Artificial Mimics. Work Package 6: Biomotors. Characterization of the SecA motor mechanism. Ursula Röthlisberger, EPFL.

neveah
Download Presentation

Work Package 6: Biomotors

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 13ns 20ns Objectives Partners PM Midterm-Review Meeting Molecular Machines- Design and Nano-Scale Handling of Biological Antetypes and Artificial Mimics Work Package 6: Biomotors Characterization of the SecA motor mechanism. Ursula Röthlisberger, EPFL Specific Targeted Research Project (STREP) in FP6-NMP-2002

  2. Midterm-Review Meeting Work Package 6: Biomotors Theoretical modeling to elucidate the structure, dynamics and ATPase activity of the SecA “motor” protein Achievements: • Refinement of the crystal structures available • Understanding the basics of ATP-induced conformational changes and the associated energy transfer in the protein • Characterization of the protein’s large amplitude motion and flexible domains Future Goals: • Use of more elaborated methods (QM/MM) to improve the understating of the SecA ATP-induced energy transfer • Study the ATP hydrolysis mechanism • Relate the conformational changes with the ATPase activity Specific Targeted Research Project (STREP) in FP6-NMP-2002

  3. Midterm-Review Meeting Work Package 6: Biomotors Conclusions: • The SecA ATP-induced microscopic changes allows us to have a clear picture of the ATP role as a source of energy for the protein translocation process • Characterization of the SecA motor mechanism translating chemical and electrostatic energy into mechanical energy can help on the construction of biomimetic analogs Resources: • 18 person-months • Computational resources provided by the Swiss National Supercomputing Centre CSCS (5000 hours per month).

More Related