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2. -X-. The Xavier Institute of Genetics. 2210 Graymalkin Lane, Salem Center, Westchester New York, 121367. Dear Applicant,
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-X- The Xavier Institute of Genetics 2210 Graymalkin Lane, Salem Center, Westchester New York, 121367 Dear Applicant, It is with great pleasure that I inform you that you have been selected by our leading team of scientists, including myself to interview for a position within “The Xavier Institute for Genetics”, a government funded research facility commissioned by the President of the United States. Successful applicants will enjoy working amongst a team of leading edge, next generation scientists, shaping the future of genetics and gene mutation. This position also holds a six figure salary, with opportunity for growth and development, within the Xavier Institute of Genetics. We are looking for responsible individuals like yourself who are; hard working, dedicated team members, who strive to push forward the boundaries of science and have an interest in exploring and developing new mutant genes, which would benefit the human race and protect our people from unforeseen events, of both natural and un natural phenomena. Your interview will be on __________________________________________________________. Please arrive on time. Successful candidates will demonstrate their knowledge of DNA Structure, Protein Synthesis, and relevant phenomena, demonstrating their ability to design and genetically engineer a new breed of Super Hero that will help facilitate and improve the safety of and help protect the development of the human race against unforeseen events and circumstances. We Look forward to meeting you, Yours Faithfully. Charles Xavier Professor M. Xavier (Founder and Executive Director of The Xavier institute of Genetics)
Scenario: Professor M. Xavier, of the Xavier Institute, has been commissioned by the President of the united States, to expand his research into DNA and protein synthesis to develop a new research wing in his facility. This wing will be dedicated to exploring and developing new mutant genes ,which would benefit the human race and protect our people from unforeseen events, of both natural and unnatural phenomena. You have been selected to apply for a position at the “The Xavier Institute of Genetics”. Successful candidates will demonstrate their knowledge of DNA structure, Protein Synthesis and relevant phenomena, to design and genetically engineer a new breed of Super Hero, that will help facilitate, improve the safety of and help protect the development of the human race against unforeseen events and circumstances. • Complete your research packet issued by “The Xavier Institute of Genetics”. • Create a superhero, describing the mutation that occurred and how it changed his or her DNA. • Present your superhero and knowledge of DNA and RNA to a team of scientists. You will be awarded 100 points. Research Packet: 70 points Oral presentation: 10 points Poster/PowerPoint: 20 points BiologyGuy
1 CHECK LIST/Grading Rubric NAME______________ PERIOD__________ XAVIER RESEARCH PACKET: 1. All pages are complete. [5] ____________________ 2. Packet is legible and shows care and effort [5] ____________________ 3. Packet has little or no content specific mistakes [60] ____________________ TOTAL_________/70 PARENT SHOWCASE (poster/presentation): 1. Students have some form of presentation; poster, video, display board [3] __________ 2. Students work is clear and well presented [5] __________ 3. Students have visuals and color on their presentation [ 5] __________ 4. Students have relevant accurate information, DNA diagrams and model, copy of one of their packets, picture of superhero, gene mutations etc. [7] __________ TOTAL______/20 ORAL PRESENTATION RUBRIC: 1. Students are well presented [1] _________________ 2. Students speak clearly using scientific vocabulary [2] _________________ 3. Students use their model to describe the structure of DNA [2] _________________ 5. Student demonstrates that they have knowledge of DNA, RNA, _________________ and protein synthesis [2] 6. Student clearly describes their superhero, the superpowers he or _________________ she has, and the mutation that caused the superhero to gain powers [2] 7. Students were able to answer the question that was posed to them _________________ by the interview panel. [1] TOTAL /10
2 1. Create a brainstorm to explore some of the issues that the human race are facing in the world of today. Are these issues natural phenomena such as weather, climate related, in the form of tornadoes, hurricanes, earthquakes and pollution? Or are they related to un natural phenomena such as war, stemming from physical conflict, between countries and civilizations? Things that affec Things that affect the environment hurricane Deforestation Natural Phenomena (example Weather) earthquake tornado wildfire pollution Global warming Things that affec Things that affect people war Un natural phenomena Crime Bullying
3 2. Now that you have explored the varying issues that are effecting the human race you need to select one or two areas which you will use as your focus in creating your new breed of genetically engineered Super Hero. Question: What ability will my Super Hero have? How will this ability benefit and protect the development of the human race. Use 8-10 sentences. ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ _____________________________________________________________________________________________
4 3. Create your Super Hero. Describe what you hope your Super Hero will look like, their personality, and character traits. Physical description: _____________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ Personality: ______________________________________________________________________________________________ ______________________________________________________________________________________________ _____________________________________________________________________________________________ Character Traits: ______________________________________________________________________________________________ _____________________________________________________________________________________________ _ ______________________________________________________________________________________________ _____________________________________________________________________________________________ _
5 4. Draw your Super Hero, include labels of key features, with annotated notes.
6 4. Here is a female superhero template. You may research other templates to help you design your Super Hero, using google search “Superhero Templates”.
4. Here is a male superhero template. You may research other templates to help you design your Super Hero, using google search “Superhero Templates”. 6
5. In order to create your new breed of genetically engineered Super Hero you need to be able to explain the structure of DNA to your interview panel. The best way to do this would be to have a detailed model. The more that you can share about your model the more impressed your panel of judges will be, resulting in a higher score and an increased chance of getting accepted into the institute. Describe the structure of DNA. What does it look like? How does its shape relate to its function? Use 6 -8 sentences 7 ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ ______________________________________________________________________________________________ You need to focus your mind. You really need to Show proficiency when describing the structure of DNA, otherwise they will laugh you right out of the room! I believe in you! M. Xavier
6. Your research team needs to find all of the required combinations that can be made from the RNA so that they can find the right amino acids needed to make the protein which will provide your Super Hero with special ability. WRITE OUT THE FULL NAME OF EACH BASE, NOT JUST THE LETTER The DNA bases are: _____________, ________________, _______________, __________________ The RNA bases are: ______________, ________________, ________________, ______________ In RNA the base Thymine changes to _________________. All of the other bases remain the same. The base pairs for DNA are : The Base pairs for mRNA and tRNA are: 8
7. In order to create your desired character traits for your Super Hero, you will need to make sure that the DNA mutation results in the correct protein being synthesized. The correct protein will then give your Super Hero the desired characteristic. Describe the process of Protein Synthesis. Step 1: DNA mRNA (transcription): __________________________________________________ _____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ Step 2: mRNA creation of amino acids (translation): _______________________________ _____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ Step 3: Amino acids chain together and form a ___________________________________. Describe how the mutation in your super hero’s DNA resulted in your super hero receiving super powers. 9 _______________________________________________________________________________________________ _______________________________________________________________________________________________ _______________________________________________________________________________________________ _______________________________________________________________________________________________ _______________________________________________________________________________________________ _______________________________________________________________________________________________ _______________________________________________________________________________________________
8. Your lab partner managed to create some of the amino acids that were required to synthesize the correct mutant protein. Unfortunately, he got sick and you need to complete his work. Write in the letters on the tRNA codons. Then, match the amino acids which are transported by the tRNA molecules to the correct bases to complete his research. One does not match! 10 tRNA mRNA U A C G G A C U U
11 9. Your research assistant wants to verify the names of the amino acids that are needed to make the protein. Use your Codon Table that you completed to provide them with the correct names. Codon 1 codes for the amino acid __________________________ Codon 2 Codes for the amino acid___________________________ Codon 3 codes for the amino acid___________________________ Codon 4 codes for the amino acid __________________________ The amino acids needed to make the protein for super X are: 1-1-2-3-4-1-2-3-1-1-2-3. Which sections of mRNA will form the correct tRNA codons and the desired amino acids? Write the mRNA codons that correspond with each tRNA below. Then write down the correct amino acid for each codon. 2. U C C 3 G A A 4. tRNA mRNA C G A 1. tRNA mRNA U A G
So….you learned about DNA, created your superhero, and completed the packetNOW WHAT?! • Use the information in this packet to create a poster or PowerPoint with the following information: • Structure and function of typical human DNA ( question 5, pg 7 of your packet) • Picture and description of your superhero and how he got his or her powers • What does your superhero do? How do the powers help? • How your superhero’s DNA is different from regular human DNA (be creative) • Your presentation should be colorful and contain pictures. If you do a poster, EVERYTHING must be typed or outlined in marker. • Completed PowerPoints done at home can be emailed to rbaron@slcd.org • Subject of email should read __________________’s superhero project • PowerPoint must be received by the due date in order to receive full credit. • For each day the project is late, 5 points will be deducted from your grade. If the project is not received by ___________________________, you will receive a phone call home.