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Stereotactic Device

Stereotactic Device. Team Members: Team Leader- Jeremy Glynn Communicator- Jeremy Schaefer BSAC- Mike Conrardy BWIG- Adam Goon Client- Ian Rowland, Ph.D., Department Of Radiology Advisor- Professor Bill Murphy. Overview. Background Information Problem Statement Motivation

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Stereotactic Device

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  1. Stereotactic Device Team Members: Team Leader- Jeremy Glynn Communicator- Jeremy Schaefer BSAC- Mike Conrardy BWIG- Adam Goon Client- Ian Rowland, Ph.D., Department Of Radiology Advisor- Professor Bill Murphy

  2. Overview • Background Information • Problem Statement • Motivation • Client Requirements • Existing Technology • Design Alternatives • Design Matrix • Future Work • Questions?

  3. Background Information • Basics of MRI (Magnetic Resonance Imaging) • Generates very strong (4.7 T) magnetic field • Causes atoms to emit radiowaves • Uses of MRI: • MR images provides information such as: • Size of tumors • Functions of organs • Chemical concentrations • Client’s focus – Brain imaging http://en.wikipedia.org/wiki/Magnetic_resonance_imaging

  4. Problem Statement • Design a stereotactic device that will: • Minimize head movement of rats/mice while positioned in MRI • Incorporate a heating device to prevent hypothermia • Fit within the MRI coil • Allow for provided anesthetic MRI Coil for imaging rats Captured 2/5/08, UW Hospital

  5. Motivation • Imaging quality and efficiency • Allow for imaging over a longer time period • Animals metabolic rates decrease with anesthesia • Can lead to hypothermia or death • Anesthetic can be connected quickly and easily • Animal can be positioned with ease • Animal safety • Current heating methods are inadequate

  6. Client Requirements • Can’t interfere with MRI images • Animals brain must be centrally aligned in MRI • Heating device to warm animal • Within 5o of 37oC • Fit inside MRI coils • Rat- 63 mm diameter • Mouse-36 mm diameter • Anesthetic mask must cover animals mouth • Minimal movement of animal • Restraint without harm • Withstand 4.7 Tesla magnetic field

  7. Existing Stereotactic Devices http://www.kopfinstruments.com/Stereotaxic/ StereotaxicPrintables/324-325-P.pdf Enzyme Research Facility (Beth Rauch) • David KOPF Instruments • Model 324 MRI Head Holder for Rat • Model 325 MRI Head Holder for Mouse • Model 923M MRI Mouse Gas Anesthesia Adaptor • Enzyme Research Facility

  8. Our Restraining Device • Tooth restraint does not obscure anesthetic mask. • Fits inside MR tray • Recessed in tray for proper brain alignment.

  9. Air Chamber • Advantages • Inexpensive • Disadvantages • Difficult to move heated air efficiently • Air has less effective heat transfer • Larger volume of air to heat

  10. Fluid Piping • Advantages • Easy to manufacture • Water has better thermal conductivity • Accessory parts inexpensive • Disadvantages • 3D printing expensive • Possibility water could leak

  11. Air Piping • Advantages • Easy to manufacture • No possibility of leaking water • Disadvantages • Air has low thermal conductivity • Difficult to move heated air through small diameter tube

  12. Design Matrix

  13. Future Work • Research: • Pumping/Heating design • Start up time • Efficiency • Testing: • Heat lost through piping • Durability of 3D printing material • Temperature of heating pad • Temperature of fluid

  14. Questions?

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