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ON- und OFF-Switches

ON- und OFF-Switches. OFF-Switch: Bindung des Liganden schaltet die Genexpression ab - zuerst entdeckt (2002) (FMN- Riboswitch in B. subtilis ; thi -Riboswitch in E. coli ) Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria.

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ON- und OFF-Switches

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  1. ON- und OFF-Switches OFF-Switch: Bindung des Ligandenschaltet die Genexpressionab -zuerstentdeckt (2002) (FMN-Riboswitch in B. subtilis; thi-Riboswitch in E. coli) Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria. Mironov AS, Gusarov I, Rafikov R, Lopez LE, Shatalin K, Kreneva RA, Perumov DA, Nudler E. Cell 2002 (5):747-56. Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Winkler W, Nahvi A, Breaker RR. Nature 2002 (419):952-6. ON-Switch: Bindung des LigandenschaltetGenexpression an -späterentdeckt (Adenosin-Riboswitchkann ON- oder OFF-Switch sein) Adenine riboswitches and gene activation by disruption of a transcription terminator. Mandal M, Breaker RR. Nat Struct Mol Biol. 2004(11):29-35 lInzwischenkennt man für die meistenLigandensowohl ON- alsauch OFF-Switches.

  2. Kälte-sensitiverRiboswitch (oder RNA-Thermometer?) Die mRNA für das ‘cold-shock’-Protein CspA in E. coli kann in Abhängigkeit von derTemperatur 2 alternative Strukturenannehmen. ErstesBeispielfür mRNA-Struktur, deren Expression beiKälterschockerhöhtist • Giuliodoriet al. Mol. Cell 2010

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