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Solving Problems with Biology … via Linked Data. 21st Century will be the Age of Biology. Climate Change. Nutritious Food. Sustainable Energy. Disease and Ageing. The most amazing molecule. 4 letter code. - A denosine - T imine - C itosine - G uanine. - A denosine
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21st Century will be the Age of Biology Climate Change Nutritious Food Sustainable Energy Disease and Ageing
The most amazing molecule 4 letter code - Adenosine - Timine - Citosine - Guanine - Adenosine - Timine - Citosine - Guanine 2 chains, exact mirrors! Able to make copies of itself! Same genetic code for all living cells!
Creating Synthetic Biology • Genetic engineering… oversimplified DNA! Bio-fuel producing gene CO2 Biofuel
Executable Cell Biology • Cell and computers are not that different Src: http://gene-therapy.yolasite.com/process.php Activator genes Repressor genes
Where does LD fit in all of this? • Let’s make a “virtual” experiment Which gene?
Non-toxic biofuel Not-soluble H2O ?gene CO2
Not that simple… ?sugar ?gene ? ? ? Biofuel U de Lichtenberg et al. Science 2005;307:724-727
The Linked Data Cloud “Life sciences will drive adoption of the Semantic Web, just as high-energy physics drove the early Web.” - BioIT World, 2005
Link the Data, cure the disease What your doctor is not telling you! Drugbank ClinicalTrial Diseasome
Linked Data to track E. coli infection UK E. coli Germany E. coli
Nothing in Biology Makes Sense Except in the Light of Evolution (Dobzhansky, 1973) Source: http://www.nytimes.com/imagepages/2007/01/22/science/20070123_SCI_ILLO.html
Toss the details, understand the patterns • Navigating the genetic landscape with simplified views In cancer or … … in the cell Source: http://www.sciencemag.org/content/327/5964/425.full
Where is the data? http://linkeddata.org http://sindice.com http://www.w3.org/wiki/HCLSIG/LODD/Data