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AMINO ACIDS

AMINO ACIDS. DR. MALIK ALQUB MD. PHD. Amino acids. At physiologic pH (approximately pH 7.4) the carboxyl group is dissociated, and the amino group is pronated. High Pka. low Pka. Carboxyl group. Amino group. At physiologic pH . D-isomer. L-isomer. Amino Acids.

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AMINO ACIDS

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  1. AMINO ACIDS DR. MALIK ALQUB MD. PHD.

  2. Aminoacids At physiologic pH (approximately pH 7.4) the carboxyl group is dissociated, and the amino group is pronated. High Pka lowPka Carboxyl group Amino group Atphysiologic pH

  3. D-isomer L-isomer Amino Acids • Amino acids, Proteins are only made up of amino acids which are L-isomers.

  4. SOME EXAMPLE AMINO ACIDS glycine - the only achiral amino acid R = H alanine R = CH3 valine R = CH(CH3)2 20 different ones occur in proteins

  5. Peptide bond

  6. Classification of amino acids. • Amino acids with nonpolar side chains • Amino acids with uncharged polar side chain • Amino acids with acidic side chains • Amino acids with basic side chains

  7. THE 9 NON-POLAR AMINO ACIDS Proline has an imino group

  8. THE 6 uncharged POLAR AMINO ACIDS

  9. THE ACIDIC AMINO ACIDS

  10. THE BASIC AMINO ACIDS

  11. Which of the following compounds is an -amino acid? • Only (a) • (a) and (b) • (a) and (c) • (a) and (d)

  12. Which of the following compounds is an -amino acid? • Only (a) • (a) and (b) • (a) and (c) • (a) and (d)

  13. Which of the following amino acids is achiral? • Alanine • Aspargine • Glycine • Threonine

  14. Which of the following amino acids is achiral? • Alanine • Aspargine • Glycine • Threonine

  15. The amino acid shown below has a side chain that is • acidic • basic • nonpolar • polar, neutral

  16. The amino acid shown below has a side chain that is • acidic • basic • nonpolar • polar, neutral

  17. Disulfide bond Cysteine Cys

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