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Welcome to Molecular Biology Through Discovery Thursday , 4 September 2014 Protein

Welcome to Molecular Biology Through Discovery Thursday , 4 September 2014 Protein. General Issues. I get a 404 error while trying to view the paper chromatography presentation. General Issues. I get a 404 error while trying to view the paper chromatography presentation.

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Welcome to Molecular Biology Through Discovery Thursday , 4 September 2014 Protein

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  1. Welcome toMolecular Biology Through DiscoveryThursday, 4 September 2014Protein

  2. General Issues I get a 404 error while trying to view the paper chromatography presentation

  3. General Issues I get a 404 error while trying to view the paper chromatography presentation

  4. Fraction of participants handing in questionnairesTuesday, Sep 2 Fraction of participants handing in questionnairesThursday, Aug 28 Fraction of participants handing in questionnaires Tuesday, Aug 26 47% 39% 22%

  5. Research Proposal …I'm debating on whether or not to focus on scar tissue or birth defects. I am currently searching for a mentor but I will wait until I decide on a topic.

  6. Research Proposal judges usually give higher scores for the most original projects http://www.ipl.org/div/projectguide/choosingatopic.html

  7. I could find it but … …did not let me download the pdf. Are you sure?

  8. What is a Protein? I would like more information on how how this pertains to Bioinformatics.

  9. What is a gene?

  10. What is a gene?

  11. DNA Protein Information Structure+Function +Self-assembly CGACCATCGCCTTAGTAC How do we determine how a linear sequence folds…?

  12. What is a Protein? Amino acid

  13. What is a Protein?

  14. What is a Protein? In a straight line? Many?

  15. What is a Protein?

  16. Protein Structure Prediction Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  17. Protein Structure Prediction How long would it take? (number of structures) (seconds / structure) Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  18. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  19. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) . . . 360 360 Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  20. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) . . . . 360 360 Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  21. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) n 360 Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  22. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 100 ? = 360 Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  23. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 200 100 100 ? = =10 360 >>100 Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator

  24. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 191 >> : 1010 years (x sec/yr) 10 seconds Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator Age of the universe: How many seconds?

  25. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 191 >> : 1010 years (108 sec/yr) 10 seconds Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator Age of the universe: How many seconds?

  26. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 191 (1080 computers) >> : 1018secs 10 seconds Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator Age of the universe: How many seconds?

  27. Protein Structure Prediction How long would it take? (number of structures) (10-9second / structure) 191 >> : 1098secs 10 seconds Candidate structures #1: Φ1=0o ; Φ2=0o;… #2: Φ1=1o ; Φ2=0o;… . . .#n: Φ1=47o ; Φ2=29o;… . . . #z: Φ1=359o ; Φ2=359o;… Candidate ΔG #1: ΔG1 #1: ΔG2 . . .#n: ΔGn . . . #z: ΔGn Free energy calculator Age of the universe: How many seconds?

  28. Protein Structure Prediction

  29. What is a Protein? …more specification of R groups and what makes up the carboxyl groups How many carboxyl groups are in a protein?

  30. What is a Protein?

  31. Me Group 2: CatherineKamranKiyanteRaeMazin Group 1: PedeeJordanRachelSkyler Group 3: ChrisDarrellFarrahNavRamey Group 4: AkhilGelilaMegan WesalWilliam Problem Set 3: Problem 1

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