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CAREER: Mechano-Responsive Biomaterials Xinqiao Jia, University of Delaware , DMR 0643226

CAREER: Mechano-Responsive Biomaterials Xinqiao Jia, University of Delaware , DMR 0643226. Synthetic Polymer. Peptide. Step Growth Click Chemistry.

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CAREER: Mechano-Responsive Biomaterials Xinqiao Jia, University of Delaware , DMR 0643226

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  1. CAREER: Mechano-Responsive Biomaterials Xinqiao Jia, University of Delaware, DMR 0643226 Synthetic Polymer Peptide Step Growth Click Chemistry Synthetic scaffolds with appropriate mechano-responsiveness are required for the engineering of mechanically active tissues. The Jia Group has developed two types of mechano-responsive hydrogels by mimicking the molecular architecture and the sacrificial mechanism present in natural proteins. The first type of mechano-responsive hydrogel is derived from a multiblock copolymer composed of flexible synthetic polymer segments alternating with an alanine-rich, lysine-containing peptide that is the structural component of the crosslinking domain of the natural elastin. Covalent crosslinking of the copolymer through the lysine amines gave rise to elastomeric hydrogels with mechanical properties comparable to those of the natural elastin. When the peptide building block was terminally tagged with fibronectin-derived cell adhesive motifs, bioactive, elastomeric hydrogels were obtained. Elastin mimetic hybrid polymer (EMHP) Cross-linking via lysine amine Mechano-responsive hydrogel Top: Chemical structure of the elastin mimetic polymer. Bottom: Synthetic procedures for the construction of mechano-responsive hydrogels.

  2. CAREER: Mechano-Responsive Biomaterials Xinqiao Jia, University of Delaware, DMR 0643226 The second type of mechano-responsive hydrogels were constructed using self-assembled block copolymer micelles (BCM) as the microscopic cross-linker. The hydrogel is responsive to mechanical stimuli and can release BCM-entrapped hydrophobic drugs under mechanical control. Structural characterization of the hydrogels revealed the reversible micelle deformation and chain alignment when the BCM-cross-linked polyacrylamide (PAAm) gels were mechanically deformed. An important goal of our outreach activities is to educate students about biomedical engineering, to convey the excitement of scientific discovery, and to provide a positive influence on students’ lives. We have organized various hands-on lab demonstrations to K-12 students. These demonstrations have sparked serious scientific interest among the students. PAAm BCM Top: Schematic of BCM-crosslinked, mechano-responsive hydrogel. Bottom: Jia demonstrating hydrogel formation visiting students.

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