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Centenarians

Promoting Health in Ageing (or Aging) Annual Joint Symposium  September 26-27. Centenarians. Thomas Perls MD, MPH Geriatrics Section, Department of Medicine Boston University School of Medicine, Boston Medical Center. National Institute On Aging. OUTLINE. Demography Age claims

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Centenarians

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  1. Promoting Health in Ageing (or Aging) Annual Joint Symposium  September 26-27 Centenarians Thomas Perls MD, MPH Geriatrics Section, Department of Medicine Boston University School of Medicine, Boston Medical Center National Institute On Aging

  2. OUTLINE • Demography • Age claims • Some characteristics • Compression of morbidity? • Centenarians as a “hook” for promoting healthy aging

  3. Our Study Populations 850 long lived families 4,800 family members 79 88 93 80 96 89 84 91 The 8 Hurlburt siblings, ages 79-96 years Agnes: "none of us have canes." (http://www.time.com/time/photogallery) National Institute On Aging • 1,600 centenarians (100-119 years) • offspring (63-100 years) • 115 supercentenarians (110+ years)

  4. New England Centenarian Study

  5. Sakhan Dosova celebrated what she, her family and Kazakh officials all agree was her 130th birthday

  6. 10 categories of false claims Our review of invalid age claims of 115 years or older resulted in the creation of ten categories of how these false claims emerge: • Religious Myth • the Village Elder • Fountain of Youth (substance) • Shangri-La (geographic) • Nationalist Pride • Spiritual Practice • Familial Longevity • Individual and/or Family Notoriety • Military Service • Pension Fraud Robert Young, Bertrand Desjardins, Kirsten McGlaughlin, Michel Poulain, Thomas Perls. Typologies of Extreme Longevity Myths. Curr Gerontol Geriatr Res, 2010.

  7. Three Types of Centenarians Based on the age of onset of heart disease, diabetes, cancer, skin cancer, osteoporosis, thyroid condition, hypertension, stroke, dementia, and COPD. The survivors: onset of disease before the age of 80 (42%) The delayers: onset of disease at or beyond the age of 80 (45%) The escapers: reaches 100 without the onset of disease Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003;58: 232-237

  8. The delayers: onset of disease at or beyond the age of 80 The survivors: onset of disease before the age of 80 The escapers: reach 100 without the onset of disease Diseases included in this analysis were: cancer, cardiovascular disease, COPD, dementia, diabetes, and stroke.

  9. Exceptional Health Span

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  12. 85 Supercentenarians(age 110-119 yrs) (Sample of 30 supers: Perls et al, Journal American Geriatrics Society, August, 2006)

  13. Personality Domains Conscientiousness Extraversion Openness Agreeableness

  14. Nature vs. Nurture • 70% environmental, 30% genetic to reach mid to late 80’s • Evidence for an increasing genetic component for older ages: • Familial clustering • Siblings with marked increased relative probabilities of living to 100+ years • Offspring with marked decreased risks for age related diseases such as heart disease, stroke, diabetes, cancer • Power to discover genetic variants associated with exceptional longevity increases with age • What kind of genetic variants? Disease vs. Protective

  15. AGEING <88 years> Attitude Genetics Exercise Interests Nutrition Get rid of (smoking & anti-aging quackery)

  16. 16 www.livingto100.com

  17. The Quacks Are Flocking 1994 U.S. congressional passage of the Dietary Supplements Health and Education Act (DSHEA) 70 Million Baby Boomers The Internet

  18. Linda M. Alan D. Kathy T. Ken B.

  19. HGH

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