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Polypropylene bottle. Funnel. Filter paper. pH-7HEPES buffered saline (HBS-7) or pH-6HEPES buffered saline (HBS-6). (20 ml, 36.5 ℃ ). Y 2 O 3 microspheres (0.05 g). 3 cm, 120 strokes·min -1. ICP analysis (Y). Calculation of dissolution ratio of Yttrium.
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Polypropylene bottle Funnel Filter paper pH-7HEPES buffered saline (HBS-7) or pH-6HEPES buffered saline (HBS-6) (20 ml, 36.5℃) Y2O3 microspheres (0.05 g) 3 cm, 120 strokes·min-1 ICP analysis (Y) Calculation of dissolution ratio of Yttrium molar quantity of Y released from microspheres to HBS total molar quantity of Y contained in 0.05g of microspheres Test of chemical durability of Y2O3 microspheres.
1.0 YAS - HBS-6 Dissolution ratio of Y / mol% 0.5 Y2O3 - HBS-6 YAS - HBS-7 Y2O3 - HBS-7 0 0 5 10 15 20 25 Time / d Dissolution ratio of YAS glass microspheres, as-prepared Y2O3 and acid-treated Y2O3 microspheres soaked in HBS-6 at 36.5ºC for various periods. (Acid treatment : soaking in HBS-6 at 36.5ºC for 5 d.)
Motor (0.5ml∙min-1) Imaging agent Catheter Liver Y2O3 microspheres Catheter Injection of Y2O3 microspheres.
Y2O3 microspheres Micro X-ray transmission image of the rabbit liver section.
Hyperthermia • Cancer cell are perished at 43ºC • Normal cells are not destroyed up to about 48ºC. Hyperthermia of cancer
Conventional hyperthermia • Hot water • Infrared ray • Ultrasound • Microwave External energy source Difficulty in heating deep-seated tumors locally
B P : heat generation (W・g-1) f : frequency (Hz) B: magnetization (emu・g-1) H : magnetic field (Oe) H Hysteresis loop Heat generation (P) by magnetic hysteresis loss.
Bioactive matrix of glassy or crystalline CaO∙SiO2 Ferrimagnetic magnetite (Fe3O4) Fe2+ Fe3+ Heattreatment Fe3+ Fe2+ Fe2+ Fe3+ Fe3+ Fe3+ Fe2+ Fe2+ CaO∙SiO2 Glass Glass-ceramic Preparation of bioactive and ferrimagnetic glass-ceramic.
TEM photograph of the glass (composition: Fe2O3 40, CaO∙SiO2 60, B2O3 3, P2O5 3 wt ratio) heat-treated up to 1050ºC; M: magnetite, W: wollastonite
30 Magnetization / emu∙g-1 20 10 3 -1 -10 -3 1 10 Magnetic field / kOe -10 -20 -30 Magnetization curve of the glass (composition: Fe2O3 40, CaO 40, SiO2 60, B2O3 3, P2O10 3 wt ratio) heat-treated up to 10100ºC.
Bioactive and ferrimagnetic glass-ceramic. (powder 100 - 1100 µmf)
Magnetic Pole 100mm Max Max 100KHz 300 Oe 2100mm 210KW Magnetic Pole Generation of alternating magnetic field