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HERHANGİ BİR ÇIKAR ÇATIŞMASI YOKTUR…. Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment. DR.ARZU DİDEM YALÇIN. Apoptosis. Mitosis. . . Artışı da Azalışı da. ÇOK HÜCRELİ CANLILARDA HÜCRE SAYISININ KONTROLÜ.
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Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment DR.ARZU DİDEM YALÇIN
Apoptosis Mitosis Artışı da Azalışı da ÇOK HÜCRELİ CANLILARDA HÜCRE SAYISININ KONTROLÜ
İç (mitokondri) ve dış (DR) apopitotik sinyal yolları. İki sistem arasında etkileşim vardır.
Mitokondriyal Yol Ölüm Resreptörleri Yolu seramid diğerleri oksidanlar FasL Fas/Apo1 /CD95 DNA hasarı D D Bcl-2 D D D FADD DISC Procaspase 8 Apaf -1 BID Procaspase 9 Cytochrome c Procaspase 3 Caspase 8 Apaf -1 dATP dATP Caspase 3 Hücresel Hedefler Caspase 9 apoptozom Hengartner, M.O. 2000. Nature. 407:770. Green, D. and Kroemer, G. 1998. Trends Cell Biol. 8:267. Memeli Hücresindeki Major Apoptotik Yollar
TRAIL-R1/R2 HÜCRE YÜZEYİ PROKASPAZ-8 / 10 FLIP FLIP FADD?, TRADD? KASPAZ-8 / 10 PROKASPAZ-3 KASPAZ-3 DİĞER KASPAZLAR ? HÜCRE ÖLÜMÜ PARP KLİVAJI, DNA DEGRADASYONU TRAIL-R ARACILIKLI HÜCRE ÖLÜMÜ YOLAĞI
Yalçın AD, Öncel S, Akcan A, Eravşar K, Polat HH, Terzioğlu E. Prevalance of allergic asthma, rhinitis and conjunctivitis in over 16 year old individuals in Antalya . Turkiye Klinikleri J Med Sci 2010; 30(3):888-94 Yalçın AD, Ozdemir L, Polat HH. Evaluation of the Patients receiving Allergen-specific Immunotheraphy In Antalya. 2011 (BMJ)
Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment Yalcin AD, Bisgin A, Cetinkaya R, Gumuslu S. Clinical efficacy of omalizumab in severe persistent asthma and co-morbid conditions. The American Journal of Case Reports, 2011; Yalçın AD. Clinical Efficacy And Side Effect Of Omalizumab .Brat Med Journal 2011; (in press) Yalçın AD, Bisgin A, Kargi A, Kose S, Terzioğlu E, Gorczynski RM. Efficacy of omalizumab and specific subcutane immunotherapy as a treatment modality in allergic asthmasAPAllergy and immunology(in press) Yalçın AD, Gorczynski RM ,et al.Total antioxidant capacity, hydrogen peroxide, malondialdehyde and total nitric oxide concentrations in patients with severe persistent allergic asthma: its relation to omalizumab treatment. American journal of Rhinology and allergy.American journal of Rhinology and Allergy. (in press) Omalizumab (trade name Xolair), a recombinant humanized monoclonal antibody to IgE, is recommended as one (new) option for the treatment of severe persistent allergic (IgE mediated) asthma .
Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment
Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment
Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment The results for patients in both groups were compared with those of healthy subjects. These data were analyzed using SPSS version 13.0 for Windows (SPSS Inc., Chicago, IL, USA). Independent two samples t-test were used for comparison of two intergroups. Wilcoxon's matched-pairs signed-rank test were used for comparison of two dependent intergroups. Serum sTRAIL levels in all individuals (patients and healthy controls) were measured by a sandwich enzyme-linked immunosorbent assay (Diaclone, France).
Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to Omalizumab treatment
TEŞEKKÜRLERarzu didem yalcin adidyal@yahoo.comProf.Dr.Reginald M GORCZYNSKI, BA, MD, PhD: Transplant Unit, Division of Cellular & Molecular Biology, Toronto Hospital, University Health Network, Toronto, ON, Canada.Assoc .Prof. Dr. Ramazan CETINKAYA, MD: Division of Nephrology, Antalya Education and Training HospitalProf. Saadet GUMUSLU, PhD: Department of Biochemistry, Akdeniz University Faculty of MedicineAssoc. Prof. Dr. Sukran KOSE, MD: Allergology and Clinical Immunology Unit, Izmir Tepecik Education and Training Hospital.Prof. Dr. Ender TERZIOGLU, MD: Department of Allergology and Clinical Immunology, Akdeniz University Faculty of Medicine.