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Pathology quiz . Week 31 MSK. Osteoarthritis Severe at the hip erosion of cartilage cyst formation osteophyte. Scoliosis Secondary to OA the vertebrae and/or discs on one side of the spine weaken or degenerate more than those on the other side, creating a curve Disc degeneration
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Pathology quiz Week 31 MSK
Osteoarthritis • Severe at the hip • erosion of cartilage • cyst formation • osteophyte
Scoliosis • Secondary to OA • the vertebrae and/or discs on one side of the spine weaken or degenerate more than those on the other side, creating a curve • Disc degeneration • ostephytes
OA • Severe kyphosis • Degeneration of discs • Anterior ostephytes • Schmorl’s nodes • protrusions of disc material into the surface of the vertebral body
Chronic RA • Fibrous tissue surround the knee joint
Chronic RA • Marked osteoporosis in both joints • Dislocation of knee joint • Ankylosis of hip joint • Thinning of cortex of bone • Marrow hyperplasia in femur due to hypersplenism and long term glucocorticoid therapy.
Osteoporosis - Gross reducation in number and size trabeculae
RA • Thickened and hyperplasticsynovium • hyperplasticsynoviocytes (blue) • Chronic inflammation (red)
RA • Rheumatoid nodule • From elbow of 66 yo man • Present in 20% of RA patients, usually with more aggressive form of RA. • Palisadingepitheloid cells • Fibroblasts and macrophages • pink amorpheus fibrin staining center – degenerated collagen
OA • 50 yo patient with haemophilia • Hx of hemoarthrosis • haemosiderosis of the synovium • Erosion of cartilage
Gout • Aggregates of urate crystals surrounded • by foreign body giant cells • Needle-shaped urate crystals
Gout • First metatarso-phalangealjoints • urate is deposited both within joints and extra articular tissue
Severe ankylosingspondylitis • Fracture of cervical spine from fall • Compression and necrosis of cervical cord • Ossified longitudinal ligaments • Replaced intervertebral discs
Septic arthritis • in head of humerus • S.aureus • Destruction of articular surface
Septic arthritis TB • Compression of spinal cord
HPO • Hypertropic pulmonary osteoarthropathy • new bone formation under the periosteum • Malignant pleural mesothelioma