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September 26 , 2011

Dynamic materials for controlling the cell microenvironment and drug release April M. Kloxin, Assistant Professor Chemical Engineering and Materials Science and Engineering College of Engineering. September 26 , 2011. Hydrogels for controlled cell culture.

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September 26 , 2011

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  1. Dynamic materials for controlling the cell microenvironment and drug releaseApril M. Kloxin, Assistant ProfessorChemical Engineering and Materials Science and Engineering College of Engineering September 26, 2011

  2. Hydrogels for controlled cell culture Molecular Details Macroscopic Structure human mesenchymal stem cells Live/Dead stain (Scale, 100 μm) What are the important microenvironment signals for directing cell function in tissue regeneration or disease progression? AM Kloxin, JA Benton, KS Anseth, Biomaters31 (2010) 1-8 AM Kloxin, MW Tibbitt, KS Anseth, Nature Protocols5 (2010) 1867-1887 AM Kloxin et al., Advanced Materials 22 (2010) 61-66

  3. Biomaterials approach to understanding and directing cell function Fundamental biological questions Biomaterials development Tissue regeneration or disease treatment Ligament Fibrocartilage • MSC homing, function, and fate • Breast cancer cell dormancy/activation • Size- & time-scales for optimal drug release • Complex tissue regeneration • Model system and targets for disease regulation • In situ multiple-trigger drug delivery Bone Responsive Materials AM Kloxin, CJ Kloxin, CN Bowman, KS Anseth, Adv Materials22 (2010) 3484-3494 MW Tibbitt and KS Anseth, Biotech Bioeng103 (2009) 655-663 Image (right): ES Place, ND Evans, MM Stevens, Nature Materials 8 (2009) 457-470

  4. Responsive materials platform for dynamic cell culture • Property control on multiple • size scales: nano-, micro-, and meso-scale • time scales: seconds/minutes, hours, and days • Appropriate physical structure and chemical functionalities Biomimetic tethers include peptide ECM mimics, cytokines, and growth factors Similar platform can be used for controlled drug release with multiple triggers AM Kloxin, AM Kasko, CN Salinas, KS Anseth, Science 324 (2009) 59-63 BD Fairbanks, …, KS Anseth, Adv Mater 21 (2009) 5005-5010

  5. Our Facilities & Team Offices 207 Colburn 129 Colburn (students) Materials & Assays 220 & 221 Colburn Cell Culture 126 Colburn (Colby Lab) Collaborators Kenneth van Golen (UD) Kristi Kiick (UD) David Colby (UD) Raja Sivamani (UC-Davis) The Group Eric Macedo Matthew Rehmann Dynamic Materials & Regenerative Medicine AprilKloxinGroup.org Funding Pilot Project, NIH COBRE P20-RR016458 Pilot Project, NIH COBRE P20-RR017716

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