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BIOMECHANICAL PROPERTIES OF THE CORNEA IN PSEUDO-EXFOLIATION SYNDROME

BIOMECHANICAL PROPERTIES OF THE CORNEA IN PSEUDO-EXFOLIATION SYNDROME. Aylin Kılıç Ertan, MD Özgür Bilen, MD Kudret Eye Hospital, Ankara, Turkey There is no financial interest. IOP measurement depends on: Corneal thickness Corneal curvature Corneal rigidity ?.

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BIOMECHANICAL PROPERTIES OF THE CORNEA IN PSEUDO-EXFOLIATION SYNDROME

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  1. BIOMECHANICAL PROPERTIES OF THE CORNEA IN PSEUDO-EXFOLIATION SYNDROME Aylin Kılıç Ertan, MD Özgür Bilen, MD Kudret Eye Hospital, Ankara, Turkey There is no financial interest

  2. IOP measurement depends on: • Corneal thickness • Corneal curvature • Corneal rigidity ?

  3. Low CH is a risk factor for a tendency toward IOP underestimation • Falsely low IOP readings create the risk for misdiagnosis of potential glaucoma patients with PSX, resulting in missed or delayed glaucoma detection.

  4. Figure courtesy of Reichert • Corneal Hysteresis (CH) • visco-elastic corneal tissue response to a dynamic deformation • difference between inward and outward applanation pressures • Corneal resistance factor (CRF) • Linear combination of inward andoutwardapplanation pressures, designed for maximal correlation with central corneal thickness • CH and CRF : between 8 and 15 mmHg.

  5. Low Hysteresis • Keratoconus • Fuchs • After corneal laser ablation • Pseudoexfoliation syndrome ??

  6. Purpose • To compare corneal biomechanic properties between eyes with pseudo-exfoliation syndrome (PSX) and normal eyes

  7. Method • Prospective study • 76 eyes of 76 patients • Group 1: PSX (+), 41 eyes • Group 2: control, 35 eyes • CH, CRF and IOPcc were compared according to groups

  8. Including criterias in Group 1: • eyes with manifest PSX material in precapsular layer and with or without PSX on pupil edge 2. eyes without glaucoma diagnosis

  9. Results Gr 1 Gr 2 p value PSX(+) PSX(-) IOPcc (mmHg) 18,7 17,6 0.05 CH (mmHg) 8,4 9,5 0.05 CRF (mmHg) 8,9 10,0 0.05 T-test

  10. Conclusion • There is low hysteresis in eyes with PSX without glaucoma • This may cause misdiagnosis of potential glaucoma patients • Special attention is necessary during IOP monitoring in eyes with PSX

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