Prof . S .І. Shkrobot

1. Principles of anatomical structures and function of nervous system. Unconditioned reflexes. Active movements system (symptomatic and topical diagnostics of movement disturbances) Prof. S.І. Shkrobot

2. Neurology as science Neuropathology (from Greek neuro – nerve, pathos – disease, logos – science) – is a part of clinical medicine, which is involved in nervous diseases and its role in pathology of other organs and systems of human body

3. Functions of nervous system The main function of nervous system is unification and regulation of different physiological processes. That means that nervous system unites, integrates and subordinates all the parts of human body and provides its connection with environment.

4. Functions of nervous system • The base of nervous system activity is reflex principle • Reflex – is a reaction of our organism to various outside and inside effects. It is provided by nervous system.

5. Reflex consists of: • afferent part (which accepts information) • central part (that keeps information) • efferent part (that creates response). As a result we have a circle – like structure - receptor (primary information centre) – programme centre – executive apparatus.

6. Reflex arche

7. Reflexes are divided into: • simple and complex • inborn and trained • conditioned and unconditioned

8. Unconditioned reflexes: • They are inborn ones • They are phylogenetically old, that means they were formed in course of phylogenesis • They are based on certain anatomic structures (segments of spinal cord or brain stem) • They exist even without brain cortex influence • They are inherited • They can be regulated by brain cortex • They are basis for the conditioned reflexes

9. Conditioned reflexes: • They are the result of the individual experience and are formed during ontogenesis • They are unstable, that means they need constant support • They aren’t based on certain anatomic structures • They are fixed in brain cortex There are such conditioned reflexes as speaking, writing, reading, calculation, practice

10. Unconditioned reflexes are divided into: • Superficial and deep • Simple and complex

11. Unconditioned reflexes are divided into: • Proprioceptive (stretch, periosteal, joint) • Exteroceptive (dermal, from mucouse membrane) • Interoceptive (from mucouse membrane of internal organs – for example urination in case of internal sphincter irritation)

12. In clinical practice we evaluate the following reflexes:

15. Motor system Provides conduction of nervous impulse from brain cortex to muscles. The way of this impulse is known as motorway or tractus corticomuscularis. It consists of two neurons: • central • peripheral

16. Upper and lower extremities, neck, trunk and perineum muscles’ innervation • The first (central) neuron is called tractus corticospinalis. • The second (peripheral) neuron is called tractus spinomuscularis.

17. The first (central) neuron

18. The first (central) neuron

19. tractus corticomuscularis

21. tractus corticomuscularis

23. Spinal nerve gives 4 branches: • ramus anterior ( together they form plexus – cervical, brachial, lumbar and sacral) • ramus posterior (it is spinal nerve, which innervates posterior trunk muscles) • ramus meningeus • ramus comunicante albi

26. Conclusions: • The muscles of upper and lower extremities have unilateral cortical innervation from contralateral hemisphere • The muscles of neck, trunk and pelvic organs have bilateral innervation from both hemispheres. In case of unilateral pathologic focus these structures do not suffer

27. Face, tongue and pharynx muscles innervation This way is called tractus corticomuscularis. • The first central neuron is called tractus corticonuclearis. • The second peripheral one is called tractus nucleomuscularis.

29. Face, tongue and pharynx muscles innervation

30. We can make the following conclusions: • 1. The face muscles have bilateral cortex innervation except the mimic muscles and tongue muscles that have unilateral innervation from the opposite hemisphere. • 2. The muscles of upper and lower extremities, lower mimic muscles and tongue muscles have unilateral cortical innervation. • 3. All the other muscles (the muscles of neck, trunk, perineum, m. oculomotorial, m. masseter, pharyngeal and palatal muscles) have bilateral cortical innervation.

31. Paralysis • Paralysis (plegia) - means the absence of active movements. It occurs in case of complete lesion of motor way (tractus corticomuscularis) . • Paresis occurs in case of incomplete lesion of motor way. That means disorders of active movements • Clinically can be – hemi-, tetra-, mono-, tri- and paraparesis.

32. Paralysis is divided into: • Central (spastic) • Peripheral (flaccid) Central or spastic paralysis is caused by the lesion of central neuron and its fibers (tr. corticospinalis or tr. corticonuclearis). Peripheral or flaccid paralysis is caused by the lesion of peripheral neuron (tractus spinomuscularis or tractus nucleomuscularis).

33. Features of central (spastic) paralysis are: 1. It is a diffuse paralysis 2. There is spastic hypertonus of muscles 3. Hyperreflexion of stretch and periostal reflexes 4. There are pathologic reflexes. They are considered to be reliable signs of central paralysis 5. Protective reflexes (the reflexes of spinal automatism) 6. Pathologic synkinesisis involuntary movements in paralysed extremity

34. Paresis

35. Paresis

37. Spastic hypertonus features: • Tonus is increased in the group of flexors in upper extremities and in the group of extensors in lower extremities • “clasp – knife“ symptom • in course of evaluation tonus decreases

38. Flexing pathological reflexes • Bechterev’s sign • Jukovski sign • Rossolimo (Venderovych) reflex

39. Rossolimo (Venderovych) reflex

40. Jukovski sign

41. Extension pathological reflexes

42. Extension pathological reflexes

43. Pathologic reflexes on upper extremities: • Bechterev’s sign. This is simply a muscle-stretch reflex of bending of fingers obtained by tapping the back of hand with a reflex hammer. • Jukovski sign. This is caused by hammer impact on a palm under fingers; response is reflex flexing of II-V fingers. • Rossolimo (Venderovych) reflex: This is simply a muscle-stretch reflex obtained by tapping the palmar surfaces of the fingers with a reflex hammer; the response is reflex flexing of II-V fingers.

44. Pathologic reflexes on upper extremities: • Tremner reflex. This is simply a muscle-stretch reflex obtained by tapping the palmar surfaces of the nail-phalax of II – V fingers. The response is fingers flexing. • Jakobson – Laske reflex. This is caused by hammer impact on processus styloideus; the response is reflex flexing of II-V fingers. • Klipel –Veil reflex. This is caused by passive bending of II – V fingers. The response is thumb flexing

45. Protective reflexes (the reflexes of spinal automatism ) • They also are one of signs of lesion of motor way. • They are especially clearly expressed at cross lesion of a spinal cord (dissociation of underlaying segments of the last from a brain). • The result is squeezing of foot, and also an injection or sharp plantar flexion of toes (V.M.Bechterev). • The response reflex flexion of paralyzed extremities, flexion in femoral, knee and talocrural joints (shortly reaction); opposite extremities thus straightens, being unbent in joints (long reaction). • Serial putting irritations on one and the other leg, can result in imitation of automatisms of walking.

46. Pathologic synkinesis • - are involuntary movements in paralysed extremity . They are observed while moving by healthy extremity. Synkinesis are divided into: • Global • Coordinatory • Imitating

47. Central paralysis

48. Features of peripheral paralysis 1. Areflexion or hyporeflexion 2. Atonia or hypotonia 3. Muscular atrophy 4. Fasciculation of muscles 5. It is limited paralysis 6. There is reaction of degeneration.