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Acquired Immunity

Acquired Immunity. Hugh B. Fackrell filename : Kuby 01B7. Acquired Immunity: Outline. Acquired vs Innate Immunity Functions of Acquired Immunity Humoral Immunity: antibody Cell Mediated Immunity Role of Macrophages Regulation of Immunity Next. Acquired Immunity: Definitions.

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Acquired Immunity

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  1. Acquired Immunity Hugh B. Fackrell filename : Kuby 01B7

  2. Acquired Immunity: Outline • Acquired vs Innate Immunity • Functions of Acquired Immunity • Humoral Immunity: antibody • Cell Mediated Immunity • Role of Macrophages • Regulation of Immunity • Next

  3. Acquired Immunity: Definitions • Acquired Immunity • Antigen • Immunogen • Humoral Immunity • Cell Mediated Immunity • Next

  4. Acquired Immunity: Objectives • Definethe following terms: Antigen, immunogen, acquired immunity, humoral immunity, cell mediated immunity • Identify the cells of the acquired immune response from light or electron micrographs • Identify the functions of the cells of the acquired immune reponse • Next

  5. Acquired Immunity • Definition • Acquired immunity( AKA adaptive immunity) is an altered reactivity to a specific compound after exposure to that compound • Characteristics • Specificity • Memory • Next

  6. The altered reactivity will not be to all compounds, just those compounds to which the animal has been exposed The animal has a heightened specific response on second and subsequent exposures because the body ” remembers” previous contacts Next Acquired ImmunityImportant Features

  7. Functions of Acquired Immunity Discriminate between self and non self for: • Defense • destruction of foreign molecules • Homeostasis • removal of dead or damaged cells • Surveillance • control of mutant or cancer cells • Next

  8. Acquired Immunity has Two Forms • Humoral Immunity • lymphocytes react INDIRECTLY on non self molecules via antibodies • Cell Mediated Immunity • Lymphocytes actDIRECTLY on the non self molecules • Next

  9. Lymphocytes

  10. IMMUNOGEN: triggers immunity and combines with products Immunogen vs Antigen ANTIGEN: combines with the products of an immune response

  11. Antigen: interaction

  12. Immunogenicity is not an inherent characteristic of a molecule Immunogen MUST first be recognized as foreign by the body Next Remember

  13. Adaptive vs Innate Immunity

  14. Primary vs Secondary Responses

  15. HumoralImmunity

  16. Antibodies Distinguish Between • Diseases • measles & mumps • Macromolecules • proteins, complex carbohydrates • Molecules • amino acids, sugars • Submolecular Structures • D& L isomers; ortho, meta, para positions • Next

  17. B cell blasts

  18. B Cell Transformation

  19. Clonal Selection: B cells

  20. Immunglobulin on B cells

  21. Plasma cell function

  22. Antibody: a Flexible mediator

  23. Plasma cell: function

  24. Complement functions

  25. Cell Mediated Immunity

  26. T cell blasts

  27. T cell blasts: structure

  28. T cells

  29. Cell mediated clonal selection

  30. T cell transformation

  31. T cells ANAE stain

  32. Role of Macrophages

  33. Monocyte

  34. Monocyte structure

  35. Macrophage Activation products

  36. Macrophages & T cells

  37. T cells interacting with Macrophage

  38. Macrophage mediatiors:CD14 receptor

  39. Macrophage mediators:CD14 & LPS receptors

  40. Endotoxin induction of Macrophage mediators:direct induction

  41. Oponsization: mechanisms

  42. Regulation of Immunity

  43. Range of immune responses

  44. Antigen Processing

  45. Cellular interactions during the humoral response

  46. A Complete Immune Response • Lymphocytes • B cells • T cells • Macrophages • critical accessory cells • Complement • combines with antibody to enhance destruction • Next

  47. White Blood Cells

  48. Adverse effects of Immunity

  49. The End

  50. Acquired Immunity:Questions • How does clonal selection contribute to memory in the immune response? • Name three feature of a secondary immune response that make it different from a primary immune response.

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