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Are Patients Dying from Hyperoxia?

Are Patients Dying from Hyperoxia?. Stephen Trzeciak, MD, MPH Cooper University Hospital Camden, New Jersey. Potential Mitochondrial Effects of Hyperoxia after Cardiac Arrest.

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Are Patients Dying from Hyperoxia?

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  1. Are Patients Dying from Hyperoxia? Stephen Trzeciak, MD, MPH Cooper University Hospital Camden, New Jersey

  2. Potential Mitochondrial Effects of Hyperoxia after Cardiac Arrest [LDH = lactate dehydrogenase; PDHC = pyruvate dehyrogenase complex; TCA = tricarboxylic acid; NAD = nicotinamide adenine dinucleotide; PTP = permeability transition pore; ETC = electron transport chain; ATP = adenosine triphosphate]

  3. Lost in Translation?

  4. JAMA 2010 303(21):2165-71

  5. U-shaped curve?

  6. “All things are poison and nothing is without poison; only the dose permits something not to be poisonous.” - Paracelsus

  7. Circulation 2011 123(23):2717-22

  8. Supranormal oxygen tension and outcome Circulation 2011

  9. Supranormal oxygen tension and outcome Circulation 2011

  10. ANZICS investigators Crit Care 2011

  11. ANZICS investigators Crit Care 2011

  12. Neurological and Cognitive Effects of Hyperoxia After Cardiac Arrest Objective:To determine if a protocol for rapid FiO2 de-escalation after ROSC from cardiac arrest reduces oxidative stress, neurological disability and neuropsychological deficits. Design:Prospective before-and-after protocol implementation study Setting:6 urban U.S. emergency departments Sponsor:National Institutes of Health (pending)

  13. Are Patients Dying from Hyperoxia? Stephen Trzeciak, MD, MPH Cooper University Hospital Camden, New Jersey

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