1 / 24

HAEMATOLOGICAL MANIFESTATIONS OF HIV

DR NEIL LITTLETON. HAEMATOLOGICAL MANIFESTATIONS OF HIV. SO HOW BIG IS THE PROBLEM?. WHAT ARE SOUTH AFRICAN DYING OF?. Tuberculosis (12%) Influenza and pneumonia Intestinal infectious diseases Heart disease CVA Diabetes HIV HPT Chronic respiratory disease Other viral diseases.

norah
Download Presentation

HAEMATOLOGICAL MANIFESTATIONS OF HIV

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DR NEIL LITTLETON HAEMATOLOGICAL MANIFESTATIONS OF HIV

  2. SO HOW BIG IS THE PROBLEM?

  3. WHAT ARE SOUTH AFRICAN DYING OF? • Tuberculosis (12%) • Influenza and pneumonia • Intestinal infectious diseases • Heart disease • CVA • Diabetes • HIV • HPT • Chronic respiratory disease • Other viral diseases

  4. WHAT IS KILLING US IN THE EC • TB • Heart disease • CVA • Influenza & pneumonia • Intestinal infections • Chronic lower respiratory tract diseases • Diabetes • Other viral diseases • HIV • HPT

  5. WHAT IS KILLING THE BIGGEST GROUP • TUBERCULOSIS • Other viral diseases • HIV

  6. WHAT IS KILLING THE MEN • TUBERCULOSIS • HIV

  7. THE NEW FACE OF HIV

  8. PRESENTATION CYTOPENIASTUMOURSBLEEDERSCLOTTERS

  9. CYTOPENIAS- PLATELETS • ITP • TTP • DIC • Dysplasia • Drugs • Hypersplenism • Aplasia • Infections- granulomatous eg TB- fungus etc • Tumours

  10. HIV INDUCED DYSPLASIA

  11. WORK UP-ITP • FBC with smear: • true thrombocytopenia vs clumps • Size of platelets, granules ( dysplasia) • Other cells:malignant, infections ( bacteria, malaria) • Fragments • Leucoerythroblastic reaction

  12. WORK UP - ITP • INR & PTT • CD 4 • ANF • BMBx • Sonar - asses splenic size AND SPLENIC VEIN SIZE

  13. CYTOPENIAS - ANEAMIA • When to investigate: 11g/dL , 10g/dL, 9g/dL, 8g/dL • Causes: production deficit or peripheral destruction or both • HAEMATINIC SCREEN • RPI, Haptoglobin, Coombs,LDH, +/- SPEP • BMBx

  14. CAUSES - ANEAMIA • ACD • Drugs- AZT/ Bactrim • Infections - Parvovirus / HBV/ HCV/CMV/ HIV • PRCA - Drugs( ARV's rare), T cell auto immunity • BM displaced by tumour • AIHA - cold/ warm/ both

  15. TUMOURS • Hodgkin's lymphoma - AIDS defining • High grade B Cell NHL- AIDS defining • T Cell NHL ( ALC & T Angioimmunoblastic) • Low grade B Cell • Other ( CML, myeloma) • Karposi's - AIDS defining

  16. TUMOUR PRESENTATION • Often the tumour declares itself • Lymph adenopathy needs to be reacted on! • B symptoms • Abdominal distention, jaundice • Pneumonias......? Lung lesions • Irrespective of CD 4 count

  17. CLOTTERS & BLEEDERS • HIV is a thrombotic disease- don't forget • People with HIV have a higher incidence of thrombosis • Research - TBH • Acquired Haemophilia - RARE

  18. THE NEW FACE OF HIV?

  19. THE CHANGING FACE OF HIV

  20. “We live in hope.” - MOTTO OF ALOE IGAZI UNIT

More Related