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The Israeli Ministry of Health Chief Scientist Office

The State of Israel Ministry of Health. The Israeli Ministry of Health Chief Scientist Office. Chief Scientist Office. Dr. Benny Leshem, Director The Medical Research Administration. The State of Israel Ministry of Health. Chief Scientist Office. RESEARCHER. Medical Research in Israel.

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The Israeli Ministry of Health Chief Scientist Office

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  1. The State of Israel Ministry of Health The Israeli Ministry of Health Chief Scientist Office Chief Scientist Office Dr. Benny Leshem, Director The Medical Research Administration

  2. The State of Israel Ministry of Health Chief Scientist Office RESEARCHER

  3. Medical Research in Israel The State of Israel Ministry of Health • Who are the major players in the Israeli research funding arena? Chief Scientist Office • Where in Israel medical research is done? • CSO-MOH, funding Program • Numbers and Facts on funding of medical research in Israel

  4. Medical Research in Israel The State of Israel Ministry of Health Chief Scientist Office Public Research Funds in Israel (2003) International Funds (NIH, EC): 12.9 M € Charity Based Funds:2.1 M € Bi-national Funds (BSF, GIF):6.1 M € Government Funds (MOE, MOST, MOCIL, MOH):11.5 M € 32.6 M €

  5. Medical Research in Israel The State of Israel Ministry of Health Who are the major players in the Israeli research funding arena? Chief Scientist Office Where in Israel Medical Research is done? CSO-MOH, funding Program Numbers and Facts on funding of Medical Research in Israel

  6. Medical Research in Israel The State of Israel Ministry of Health Major Academic Institutes: Hebrew University*, Jerusalem Tel Aviv University*, Tel Aviv Ben Burion University*, Beer Sheba Technion*, Haifa Haifa Universiry, Haifa The Bar Ilan University, Ramat Gan The Wiezmann Institute, Rehovot ------------------------------------------------- * Include Medical Schools Chief Scientist Office

  7. Medical Research in Israel The State of Israel Ministry of Health Major Medical Centers: Hadassah*, Jerusalem Sheba*, Tel Aviv Soraski*, Tel Aviv Rabin*, Petah Tikva Soroka*, Beer Sheba Rambam*, Haifa ------------------------------------------------- * Affiliated to Medical Schools Chief Scientist Office

  8. Medical Research in Israel The State of Israel Ministry of Health Who are the major players in the Israeli research funding arena? Chief Scientist Office Where in Israel Medical Research is done? CSO-MOH, funding Program Numbers and Facts on funding of Medical Research in Israel

  9. Medical Research in Israel The State of Israel Ministry of Health Chief Scientist Office CSO-MOH: Chief Scientist Office, Ministry of Health Scope: Medical Research (health and disease linked) 0.85 M € in 2003 3% of all the support to medical research in Israel

  10. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Raison d’être Chief Scientist Office * To fills in the niche between • Foundations supporting basic science • Bio-hitech enterprises supporting applied R&D and by that bridge on the gap and “process” the basic finding to be attractive to the Bio-hitech * To foster and support medical research in hospitals

  11. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding method: Chief Scientist Office Investigator-initiated (“Bottom-up”) Review method: Study Sections (Review committees) (NIH model)

  12. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Annual Call for Applications (Depending on budget) Chief Scientist Office Research Projects* Feasibility studies* Fellowships to research-clinicians Stipends to Investigators-physicians (Research Protected Time) * Grants do not cover salaries to PI and CI, allow 10% overhead

  13. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Eligibility Chief Scientist Office All researchers with Ph.D., M.D. or equivalent degrees From any recognized research institute in Israel On any field of medical (Health- and Disease-related) research

  14. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Submission of Applications Chief Scientist Office Application forms are submitted on-line Applications are submitted by Email Printed applications are mailed to CSO-MOH

  15. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Admission of Applications Chief Scientist Office On-line submitted data are automatically integrated into CSO-MOH database Emailed files of applications are installed in a protected site in CSO-MOH server for on-line review Printed applications are also available for reviewers

  16. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Handling of applications Chief Scientist Office Applications are checked for: Eligibility Relevance to CSO-MOH scope of funding Required data on applicants, budget, Required Bio-ethical (Helsinki, Animal experimentation) and biohazard documentations Applications are allocated to study sections by field of research

  17. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Review Committees (Study Sections) Chief Scientist Office Assigned Ad-hoc Nominated chairpersons Field expert reviewers (10% new reviewers) Volunteers

  18. The State of Israel Ministry of Health Chief Scientist Office We have read your proposal and are giving it serious consideration

  19. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Review Criteria Chief Scientist Office • Scientific Merit (Hypothesis, Scientific Approach, Innovation) • Significance and potential contribution to medicine (relevance to medicine in Israel - extra) • The methods and their relevance to the aims, adequate biostatistics • The applicants and available facilities • Application organization, personnel, budget

  20. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Additional Criteria Chief Scientist Office • Encouraging investigators at the beginning of their scientific career • Encouraging research done by clinicians • Encouraging research done in peripheral hospitals • Encouraging multi-center (Academia-Hospital) collaboration

  21. The State of Israel Ministry of Health ENDANGERED SPECIES Chief Scientist Office MD-RESEARCHERS

  22. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Review Process Chief Scientist Office Fifteen-twenty applications/committee Ten-fifteen reviewers/committee Each reviewer is assigned as a primary reviewer of 2-4 applications; Prepares written reviews. Presentation of each application to the panel, 10-15 minutes discussion followed by scoring (0-100) and voting at a secret ballot Applications are reviewed “as written” Some applications may be sent to additional external reviewers, when special expertise is needed

  23. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Special Review Process Chief Scientist Office Applies for research areas to which less than 9 applications were received For those the procedure is a combination of external reviews and a study section The review committee consists of the members of CSO-MOH advisory board together with “Field Coordinators”

  24. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding Decisions Chief Scientist Office Final decisions, based on scores and Chair’s recommendations, are made by the Fund’s board. No appeals on final decisions Applicants may receive (by request) the written reviews

  25. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Reports Chief Scientist Office Financial reports: Semi-annually Progress (final) Reports: Annually

  26. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding from Other Sources Chief Scientist Office CSO-MOH review and scientific follow-up mechanism is also provided to other funding organizations supporting medical research

  27. Medical Research in Israel The State of Israel Ministry of Health Who are the major players in the Israeli research funding arena? Chief Scientist Office Where in Israel Medical Research is done? CSO-MOH, funding Program Numbers and Facts on funding of Medical Research in Israel

  28. CHIEF SCIENTIST The State of Israel Ministry of Health Chief Scientist Office

  29. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding 2001-2003 Chief Scientist Office Average grant: 15,000 € p.a. for 2 years (not including salaries, allowing 10% overhead)

  30. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding 2002-2003 (PathoGenoMics-related) Chief Scientist Office

  31. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Research Projects: Pathgenomics-related Chief Scientist Office • The role of human metapneumovirus in community- acquired respiratory tract infections in young children in Israel • Virulence determinants of group G streptococcus and emm typing of a collection of strains obtained from one hundred patients with bacteremia. • The potential use of newly isolated attenuated mutants of vaccinia virus as vaccine against smallpox

  32. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Research Projects: Chief Scientist Office • Virulence strategies of Salmonella enterica serotype Virchow: from the gene to the plate • Comparison of the virulence system required for intracellular multiplication by different pathogenic Legionella species • Proteomic assessment of genes involved in the development of the human pathogen Leishmania

  33. The State of Israel Ministry of Health Chief Scientist Office Benny.leshem@moh.health.gov.il Tel: +972-2-568-1208, Cell: +972-50-624-2187 Fax: +972-672-5833

  34. The State of Israel Ministry of Health Chief Scientist Office

  35. Hospitals מדינת ישראל משרד הבריאות לשכת המדען הראשי Industry (Clinical Research) (Development & Production) Academia (Basic Research)

  36. The State of Israel Ministry of Health Better Medicine Chief Scientist Office Better Health Longer and Healthier life

  37. The State of Israel Ministry of Health Chief Scientist Office

  38. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health After the Meetings Chief Scientist Office Scores are averaged. (Significantlydeviated scores - ignored) A cut-off score is proposed, based on available budget. Applications scored below 90 are not funded. Applications scored above cut-off score are recommended for funding.

  39. Funding of Medical Research: CSO-MOH The State of Israel Ministry of Health Funding Activation Chief Scientist Office Approval and rejection letters are sent to all applicants: “Highly scored but not funded” letters to applications scored between 90 and cut-off*. A legal contract is signed between CSO-MOH, institution’s research authority and PI * May be beneficial for the applicants for promotion and institutional support

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