Cell Biology Class 13: Receptors and Ligands Valerie Horsley

1. Cell Biology Class 13: Receptors and Ligands Valerie Horsley

2. Learning Objectives: Identify molecules that allow cells to communicate

3. How do cells respond to their environment?

4. Stimuli Chemicals Gases Proteins Light Physical force (sound) Temperature Membrane potential

5. Activation of Neuron growth Neurons dissected from chicken

6. Activation of Neuron growth B A Stanley Cohen Rita Levi-Montalcini TreatmentWhich picture? 1. None Proteins isolated from whole tumor cell Proteins isolated from Tumor Nuclei 4. Proteins in tumor culture media A B A B

7. Ligands can be Proteins Fibroblast Growth Factor Insulin Epidermal Growth Factor Nerve Growth Factor

8. Receptor classes involved in signaling Channels CB-04 Nuclear receptors CB-06 Transmembrane receptors Cell adhesion molecules CB-18 Figs. 24-1

9. Receptor classes involved in signaling Channels CB-04 Nuclear receptors CB-06 Transmembrane receptors Cell adhesion molecules CB-18 Figs. 24-1

10. Classes of Transmembrane Receptors Receptors Transducers Receptors Transducers Fig. 24-1