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Endogenous Retroviral promoter of the Human gene

Endogenous Retroviral promoter of the Human gene. Kim Tae Hyung http://www.primate.or.kr Oct 02,2004 MPL.

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Endogenous Retroviral promoter of the Human gene

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  1. Endogenous Retroviral promoter of the Human gene Kim Tae Hyung http://www.primate.or.kr Oct 02,2004 MPL

  2. King Jordan1, Igor B. Rogozin1, Galina V. Glazko2 and Eugene V. Koonin11 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A/Room N511M, 8600 Rockville Pike, Bethesda, MD 20894, USA2 Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, 328 Mueller Lab, University Park, PA 16802, USA Origin of a substantial fraction of human regulatory sequences from transposable elements Principal Research Interests Generally, we are interested in understanding the evolution of life. Specifically, to obtain glimpses of such understanding, we employ existing and new methods of computational biology to perform research in three main directions.i) Empirical comparative and evolutionary genomics - comparison of prokaryotic and eukaryotic genomes with the aim of predicting gene functions, constructing evolutionary scenarios for particular gene families and functional categories, and deciphering general evolutionary trends. One of the evolutionary phenomena we are particularly interested in is horizontal gene transfer between diverse organisms. One of the products of this research direction is the database of Clusters of Orthologous Groups of proteins (COGs).ii) Exploitation of genome comparisons, particularly those between relatively close genomes, for addressing fundmanetal issue of evolutionary biology such as the nature of adaptation and selection in different categories of genes.iii) Classification and evolutionary analysis of protein domains and domain architectures. An important dimension in this type of research is discovery of "new" domains that are shared by many diverse proteins but have not been defined previously.

  3. Types of alternative splicing events

  4. Transposable element (TE)-derived sequences in human regulatory regions The Human Promoter Database (HPD; http://zlab.bu.edu/~mfrith/HPD.html)

  5. Transposable elements (TEs) in human regulatory sequences

  6. Transposable element (TE)-derived cis-regulatory elements

  7. Sequence alignment of the -globin locus and a mammalian apparent long terminal repeat (LTR)-retrotransposon (MaLR)

  8. The types and consequences of alternative promoters

  9. Proposed mechanisms that could lead to creation of alternative promoters

  10. Selected human and rodent genes with alternative promoters

  11. Promoter activity of the ENDRB LTR

  12. Tissue specific 97 kb

  13. MID1

  14. Functional analysis of alternative MID1 promoters

  15. Antisense and RNAi

  16. Experimental analysis of alternative splicing

  17. Analysis of expressed pattern by providing ERV-derived promoter in the HESAS

  18. The statistic about ERV-derived promoter in the HESAS • Total : 135 • Internal : 38 • LTR : 97 • Known Gene : 48 • LTR-derived : 37 • Internal : 11 • Unknown Gene: 87 • (LOCXXX, FLJXXXX, MGCXXXX,….)

  19. The consequences of LTR-derived promoters in the HESAS

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