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Chapter II. Mechanisms of Hormone Action

Chapter II. Mechanisms of Hormone Action. PS Wang/ 2004.05. Mechanism of Hormone Action. 1. Peptide hormones 2. Steroid hormones. PS Wang/ 2004.05. Three categories of second messengers. Cyclic nucleotides (cAMP; cGMP) Ca 2+ Phosphatidyl inositol. PS Wang/ 2004.05.

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Chapter II. Mechanisms of Hormone Action

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  1. Chapter II. Mechanisms of Hormone Action PS Wang/ 2004.05

  2. Mechanism of Hormone Action 1. Peptide hormones 2. Steroid hormones PS Wang/ 2004.05

  3. Three categories of second messengers • Cyclic nucleotides (cAMP; cGMP) • Ca2+ • Phosphatidyl inositol PS Wang/ 2004.05

  4. Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1216

  5. Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1217

  6. Hadley Endocrinology 1988 2nd ed #1968

  7. Hadley Endocrinology 1988 2nd ed #1969

  8. Hadley Endocrinology 1988 2nd ed #1970

  9. Hadley Endocrinology 1988 2nd ed #1971

  10. Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1204

  11. Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1205

  12. Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1206

  13. Inositol Triphosphate a novel second messenger in cellular signal transduction by Berridge, M. J., & Irvine, R. F. from Nature 312: 315-321, 1984. PS Wang/ 2004.05

  14. Phospholipase C (PLC) Diacylglycerol (DG, DAG) Calcium Release #1264

  15. McDonald Veterinary Endocrinology and Reproduction 1976 2nd ed #3

  16. Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-20

  17. Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-21

  18. Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-22

  19. Prostaglandins (PG) Finding: 1934, by von Euler (Sweden), in human semen Structure: unsaturated fatty acid, 20 C Characteristics: local hormone, 4 series (E, F, A, & B) Functions: PGE ∵soluble in “ether” PGE1: bronchial dilation; platelet aggregation PGE2: bronchial dilation; abortion PGF ∵ soluble in “phosphate” (“fosfat” in Swedish) PGF2α: destruction of CL, induction of labor (late pregnancy) & abortion (early pregnancy) PGA1 vasodilation; diuresis; gastric secretion Functional mechanisms: PG Ca2+ level muscle contraction or steroid synthesis or antagonizes cAMP action in a variety of tissues PS Wang/ 2004.05

  20. #202

  21. Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1232

  22. 27 Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1233

  23. Discovery of Leukotrienes 1938 Feldbery & Kellaway Cobra Venom Dog Lung Bronchoconstrictor Agent (= slow reacting substance, SRS = leukotrienes) Whose effect lasted much longer than that of histamine (= fast reacting substance) 1940 Brocklehurst Asthmatic Patients + Pollen Lung SRS (SRS-A, A = Anaphylaxis) 4000 X more powerful than histamine on stimulation of smooth muscle in the tracheobronchial tree perfused PS Wang/ 2004.05

  24. Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1234

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