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Midori Nakamura 1,2 , Yusuke Takahara 1,2 , Saori Matsuoka 1 ,

Therapeutic vaccine- induced Gag - specific CD8 + T cells under anti -retroviral therapy contribute to viral control in a macaque AIDS model. Midori Nakamura 1,2 , Yusuke Takahara 1,2 , Saori Matsuoka 1 , Tomoyuki Miura 3 , Yoshio Koyanagi 3 & Tetsuro Matano 1,2.

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Midori Nakamura 1,2 , Yusuke Takahara 1,2 , Saori Matsuoka 1 ,

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  1. Therapeutic vaccine-inducedGag-specific CD8+ T cells under anti-retroviral therapycontribute to viral control in a macaque AIDS model Midori Nakamura1,2, Yusuke Takahara1,2, Saori Matsuoka1, Tomoyuki Miura3, Yoshio Koyanagi3&Tetsuro Matano1,2 1National Institute of Infectious Diseases, AIDS Research Center, Tokyo, Japan 2University of Tokyo, Institute of Medical Science and Graduate School of Frontier Sciences, Tokyo, Japan 3Kyoto University, Institute for Virus Research, Kyoto, Japan

  2. unvac Protocol of macaque experiment ART wks viral loads (copeis/ml) vac unvaccinated (unvac; n=6) vaccinated (vac; n=6) ART SIVmac239 i.v. P = 0.3750 P = 0.0313 ART wk 0 12 26 32 viral loads (copeis/ml) Tx vac: SeV-Gag & SeV-Vif wks Tx vac

  3. Therapeutic vaccination during ART induced Gag/Vif-specific CD8+ T-cell responses. ART wk 12 wk 26 wk 27 wk 34 P = 0.0087 P = 0.0130 Gag antigen-specific CD8+ T-cell frequencies (%of CD8+ T cells) P = 0.0152 P = 0.0238 Vif

  4. Anti-SIV efficacy of CD8+ cells was enhanced by SeV-Gag/Vif vaccination during ART. pre-ART CD8 during ART CD8 anti-SIVpre efficacy wk27 Gag-specific CD8T frequencies (log) R = 0.9429 P = 0.0167 anti-SIVpre efficacy of CD8+ cells at wk27 (log) Anti-SIV efficacy of CD8+ cells was correlated with Gag-specific CD8+ T-cell responses after SeV-Gag/Vifvaccination. Our results suggests that Txvaccine-induced Gag-specific CD8+ T cells can contribute to HIV control.

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