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Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul

Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness. Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul. Purpose.

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Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul

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  1. Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu(Orucov) Kudret Eye Hospital / Istanbul

  2. Purpose To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.

  3. Hydroxipropylmethylcellulose Hypromellose • Hydrophylic • pH: 7,2-7,9 • Osmolarity 240-300 mOsm

  4. Spoerl E,.Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007;26:385–9 Ophthalmology 2009; 116(12) 2336-9

  5. Methods Two groups were formed in patients with keratoconus undergoing cross-linking ; Grup 1. (N=18). • Epithelial abrasion (9mm) • 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. • UVA 3mw/cm2 at365nm for 30 min Grup 2. (N=21). • Epithelial abrasion (9mm) • 0.1 % Riboflavin drops in dextrane every 3 minutes and hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes. • UVA 3mw/cm2 at365nm for 30 min

  6. Central corneal thicknesses were measured by ultrasound pachimetry • before epithelial abrasion, • after epithelial abrasion and • 30 minutes after beginning riboflavin installation

  7. Group 1 Group 2 After epithelial abrasion 30 minutes after riboflavin

  8. Conclusion Decrease of corneal thickness continues with epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC. HPMC Rb+Dextran Rb+Dextran H2O H2O

  9. Thank you for your attention

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