1 / 9

glucoPHYTON

glucoPHYTON. Rationale of the project and description of ingredients. OBJECTIVES. Design of a phytonutraceutical formulation to: Control post- prandial plasma glucose levels by A) reducing glycemic index of food B) increasing glucose excretion

olaf
Download Presentation

glucoPHYTON

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. glucoPHYTON Rationale of the project and description of ingredients

  2. OBJECTIVES Design of a phytonutraceutical formulation to: Control post-prandial plasma glucose levels by • A) reducing glycemic index of food • B) increasing glucose excretion Reduce the synthesis of Advanced Glycation End products (AGEs) Reduce the synthesis of Advanced Lipoperoxydation End Products (ALEs) As a consequence of these goals, to prevent and/or to decrease complications of diabetes

  3. INGREDIENTS L-carnosine Pyridoxal-5-phosphate Morus alba Innovative blend combining inhibitors of Glycosidase, inhibitors of SGLT-2 (sodium-glucose cotransporter 2) and inhibitors of the synthesis of Advanced Glycation End products and the synthesis of Advanced Lipoperoxydation End products

  4. Apple TREE BARK PharmacologicalEvidences Phlorizinis a well-known SGLT-2 inhibitor, causing glucosuria both in dogs and humans

  5. PHARMACOLOGICAL EVIDENCES 1-deoxynojirimycin (DNJ) and some of its derivatives are well known as an alpha-glucosidaseinhibitors CLINICAL EVIDENCES • Randomized open, cross-overstudy in 10 healthywomengivenM.albaextract and selectedcarbohydrates • Suppresion of post-prandialbloodglucose and insulinlevels

  6. PHARMACOLOGICAL EVIDENCES • Carnosineinhibits in vitro low-density • Lipoproteinoxydation • Carnosinedelayssenescence of human • cultureddiploidfibroblasts CLINICAL EVIDENCES • Randomizeddoubleblind placebo controlled • study of effectsoncognition and mood in • the healthy elderly volunteers • Working memory (Bond-Lader visual analogue • Scales) increased in 28 subjects after two months • of treatment.

  7. PHARMACOLOGICAL EVIDENCES • Decrease of beta-amyloid-induced • cognitive dysfunction and neurotoxicity • Protective effect on Abeta(1-42)-induced • neuronal cell death and memory impair- • ment of mice. CLINICAL EVIDENCES • Doubleblind, placebo controlledstudy of effects of 100 mg of L-theanine • + 50 mg of caffeineon EEG and scores of attentiontests in 16 healthy • volunteers • Doubleblind, placebo controlledstudy of effects of 100 mg of L-theanine • + 50 mg of caffeineoncognition and mood in healthy volunteers.

  8. INDICATIONS HEALTHY • Increase of attention and short termmemory • Increase of cognitivefunction • Increase of alertness • Decrease of neuronal degenerationduetosenescence, toxins • and oxidativedamage PATIENTS • Decrease of neuronal degeneration in Alzheimer patients • Protective effect on environmental toxins-induced neuronal cell death • Mood improvement in children with attention deficit with hyperactivity

  9. SUMMARY • New formulationnotdescribedelsewhere • Activity of ingredientsdemonstrated in “vitro” and “in vivo • pharmacologicalstudies • Wellknown and safeingredients, most of themwith a specifmonograph in • US Pharmacopea and/orotherpharmacopeas • Ingredientseasylyavailable • Alltheingredientshaveshown beneficial effectsoncognitivefunction, • memory and mental altertness in EvidenceBasedClinicalTrials • Formulationuseful in children, adults and elderly • Formulationlikelyusefulbecauseitconsidersmost of theknownmechanismsinvolved in cognitiva function

More Related