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NATURAL PRODUCTS RESEARCH

NATURAL PRODUCTS RESEARCH. CHEMISTRY DEPARTMENT, MAKERERE UNIVERSITY. MAJOR RUNNING THEME SINCE 1998. BIOPROSPECTING FOR FLAVONOIDS IN UGANDAN FLORA. Main collaborator: Prof. Øyvind Andersen University of Bergen,Norway. The focus has been guided by the following questions:

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NATURAL PRODUCTS RESEARCH

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  1. NATURAL PRODUCTS RESEARCH CHEMISTRY DEPARTMENT, MAKERERE UNIVERSITY

  2. MAJOR RUNNING THEME SINCE 1998 BIOPROSPECTING FOR FLAVONOIDS IN UGANDAN FLORA Main collaborator: Prof. Øyvind Andersen University of Bergen,Norway • The focus has been guided by the following questions: • Have plants been used locally for medicinal purposes? • Have plants been researched for flavonoid content before? • Are the flavonoids observed in a preliminary screening new compounds or not? • Are the plants or plant parts edible

  3. Current Research Team • Prof. Bernard T. Kiremire • Assoc. Prof. Robert Byamukama • Dr. HanningtonTwinomuhwezi-Busitema University • Ms. Jane Namukobe • Ms. AdiaMadina • Mr. Christopher Adaku-Mbarara University • Collaborators: National and International to be detailed later

  4. On Going Projects in natural products 2013 1. Bioprospecting For Flavonoids In Ugandan Flora • Researchers: • Bernard. T. Kiremire, Robert Byamukama, Grace Nambatya,JaneNamukobe, AdiaMadina, Christopher Adaku 2. Multi-disciplinary University Traditional Health Initiative (MUTHI): Building Sustainable Research Capacity on Plants for Better Public Health in Africa

  5. On Going Projects in natural products 2013 -continued Collaborators University of Oslo: Prof. Berit Paulsen, Over all coordinator, Mr. Jørgen Kirksæther [Finance admin] University of Bergen:Prof. Øyvind Andersen University of Mali: Prof. Drissa Diallo Joop deJong; Mrs Charlotte van’t Klooster Oxford University: Prof.Gerry Bodeker,Dr. Merlin Willcox, University of Western Cape: Prof.Gail Hughes, University of orange Free state:

  6. France-Uganda Researchcooperation (FURC) project on plant Phytochemistry • Researchers: Bernard. T. Kiremire, Robert Byamukama, Jane Namukobe • Collaborators • John.M. Kasenene :Mountain of the Moon University • Françoise Guéritte: Institut de Chimie des Substances Naturelles, France • Vincent Dumontet : Institut de Chimie des Substances Naturelles, France • Sabrina Krief : Eco-Anthropologie et Ethnobiologie,France • Isabelle Florent :National Museum Natural History,France • John D. Kabasa : College of Veterinary Medicine, animal resources and biosecurity, Makerere university :

  7. PhD based studies

  8. Isolation and Characterization of Anti-Bacterial Constituents of Maytenus Putterlickioides,VernoniaGlabraand Thalictrum Rhychocarpum PhD student Mayeku Philip Wafula Supervisor/collaborators • Prof. Bernard Kiremire, Makerere University • Prof. AbiyYenesew, University of Nairobi,Kenya • Dr. Josiah Odalo, Jomo Kenyatta University Achievements so far • 2 Publications in International Journals

  9. Phytochemical investigation of selected plants from the family Asphodelaceae for Anti-Infective principles: PhD student Induli Martha Supervisor/collaborators • Assoc. Prof. Byamukama Robert, Makerere University • Prof. AbiyYenesew, University of Nairobi, Kenya Achievements so far • 2 Publications in International Journals

  10. Phytochemical and Antiplasmodial Studies of NeoboutoniaMacrocalyx L. PhD student • Jane Namukobe, Makerere University Supervisors • Assoc. Prof. Byamukama Robert, Makerere University • Prof. Kiremire Bernard, Makerere University Achievements so far • 2 Publications in International Journal

  11. Nutraceutical Potential of Some Ugandan Plants with Focus on Anthocyanins PhD student • Christopher Adaku Supervisor/collaborators • Assoc. Prof. Byamukama Robert, Makerere University • Prof. Kiremire Bernard, Makerere University • Prof. Øyvind Andersen,University of Bergen

  12. Phytochemistry of selected herbal remedies used by traditional herbalists in treatment of malaria in Uganda PhD student • AdiaMadina, Makerere University (MUTHI) Supervisor/collaborators • Assoc. Prof. Byamukama Robert, Makerere University • Prof. Kiremire Bernard, Makerere University • PROMETRA Uganda-Association of herbalists

  13. COMPLETED PROJECTS Characterization of anthocyanins from Selected Plants in Uganda PhD Candidate • Byamukama Robert, Makerere University, PhD Thesis, currently teaching at Makerere University. Out put 4 Publications in International Journal Thesis Publication at Makerere University

  14. COMPLETED PROJECTS Characterization and Analysis of Some Natural Dyes from Selected Plants in Uganda. Researcher • Wanyama Aaron Philip Guloba, Achievements • PhD Thesis published at Makerere University. • 5 Publications in International journals

  15. COMPLETED PROJECTS Phytochemical Investigation of ErythrinaAbyssinica, ErythrinaBurttii, ErythrinaMelanacantha And Derris Trifoliata: Towards Malaria Control. Researcher TwinomuhweziHannington Achievements • PhD Thesis published at Makerere University. • 3 Publications in International journals • Lecturership at Busitema University.

  16. COMPLETED PROJECTS • Antimalarial Activities Of Some Flavonoids And Flavonoid-Rich Plant Extracts Researcher • AkalaMiimaHoseah Achievements • PhD Thesis published at Makerere University. • 3 Publications in International journals • currently working at Kenya Medical Research Institute[KEMRI]

  17. COMPLETED PROJECTS Capacity building • 14 MSc graduates working on natural products areas (medicinal and flavonoids). • 4 PhD graduates working on natural products • 32 publications in International journals MoUs developed • MoU with PROMETRA Uganda, process completed • MoU with MUMETHA, on-going

  18. CONTRIBUTION Capacity building in terms human resource • several graduates from Natural products • Completed: 4PhDs, 14MSc • Ongoing: 5PhDs, 3MSc Contribution to science knowledge/flavoinoid chemistry • 30 novel compounds have been characterized together with several known compounds. • HPLC, GC-MS, Small equipments for isolation of natural products.

  19. FUTURE PROJECTS • Improvement of Selected Anti-malarial Herbal Medicines Through Identification of Bioactive Compounds and Development of Standardised Formulation Methods • Development of Antioxidants and Flavonoids as food supplements from indigenous plant sources • The Potential of Natural Dyes from Selected Indigenous Dye-Yielding Plants as Substitutes for Synthetic Dyes. • Pesticide properties of Plants and Their Potential in Crop Disease Control

  20. SIDA phase IV • Concept was submitted based on the four topics in our future projects • PI on the concept is Assoc. Prof. whom Prof. Kiremire has mentored through the previous Projects Required assistance. • possible collaborators from SWEDEN on the above areas of natural products

  21. CHALLENGES FUNDING • Lack of local funding from University or Government, and this sometimes creates discontinuity when the project ends and you have no other project. EQUIPMENT • Research funding usually not enough to buy big equipment vital in Natural products research such as MS and NMR. • Much reliance on collaboration in order to use large equipments.

  22. ACKNOWLEDGEMENTS • NUFU • SIDA • University of Bergen • Makerere university Thank you for listening

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