1 / 17

Nanosensors

Nanosensors. Hyunkyung Bae Byungmook Kim. Why is it needed?. How to make?. What to do?. Nanosensors. Big Issues in Biology. Google image. Properties of Nanosensors. 1. Magnetic Property. 2 . Optical property. Google image. Magnetic properties. Superparamagnetism.

olin
Download Presentation

Nanosensors

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Nanosensors HyunkyungBae Byungmook Kim

  2. Why is it needed? • How to make? • What to do? Nanosensors

  3. Big Issues in Biology Google image

  4. Properties of Nanosensors 1. Magnetic Property 2. Optical property Google image

  5. Magnetic properties

  6. Superparamagnetism • Superparamagnetism is a form of magnetism, which appears in smallferromagnetic or ferromagnetic nanoparticle. • Neel relxation time < measurement time →average zero magnetic state = superparamagnetic state • When an external magnetic field is applied to an assembly of superparamagnetic nanoparticles, their magnetic moments tend to align along the applied field, leading to a net magnetization.  N S Nanoparticle

  7. Optical properties Qd is Much Much stable! FITC Alexa 488 Organic dye Quantum dots GFP IGOR L. MEDINTZ1*, H. TETSUO UYEDA2, ELLEN R. GOLDMAN1 AND HEDI MATTOUSSI, Quantum dot bioconjugates for imaging, labelling and sensing, Nature materials 2005

  8. Fluorescence Resonance Energy Transfer

  9. How can we make it?

  10. Characterization Gold nanoparticle – Optical Dark field Quantum dots - TIRF

  11. What can we do with it? Cell/Protein Imaging Cell/Protein Manipulation Nano ruler

  12. 1. Cell/Protein Imaging 40mer lipid 63mer 82mer Lipid

  13. 2. Cell/Protein Manipulation Channel Cell

  14. 3. Nanoruler • Alexander J. Mastroianni, David A. Sivak, Phillip L. Geissler, and A. Paul Alivisatos, Probing the Conformational Distributions of Subpersistence Length DNA, Biophysical Journal 2009 • .

  15. 3. Nanoruler Dark Field – Gold nanoparticles TIRF Microscopy – Quantum dots Completely matching! Strong magnet Strong magnet Magnetic+Au Glass TIRF Microscopy Q dot • Alexander J. Mastroianni, David A. Sivak, Phillip L. Geissler, and A. Paul Alivisatos, Probing the Conformational Distributions of Subpersistence Length DNA, Biophysical Journal 2009 • .

  16. Future work

  17. References • A.P.Alivisatos, Science, New Series, Vol. 271, No. 5251. (Feb. 16, 1996), pp. 933-937 • Yadong Yin & A.PaulAlivisatos, NATURE04165, vol 437, 2005 • J. M. Yuk, J.W. Park, A. Paul Alivisatos, High-resolution EM of Colloidal Nanocrystal growth using graphene liquid cells, Science 336, 61 (2012) • J. M. Yuk, J.W. Park, A. Paul Alivisatos, High-resolution EM of Colloidal Nanocrystal growth using graphene liquid cells, Science 336, 61 (2012) • XiaogangPeng, L.Manna, W.Yang, J. Wickham, E.Scher, A.Kadavanich & A.P.Alivisatos, Shape control of CdSenanocrystals, Nature,vol 404, 2 March 2000 • L.Manna, D.J.Milliron, A.Meisel, E.C.Scher, A.PaulAlivisatos, Controlled growth of tetrapod-branched inorganic nanocrystals, nature materials, vol 2,June 2003 • Haitao Liu and A.PaulAlivisatos, Preparation of Asymmetric Nanostructures through Site Modification of Tetrapods,NanoLett., Vol. 4, No. 12, 2004 • Son, D. H.; Hughes, S. M.; Yin, Y. D.; Alivisatos, A. P., Cation exchange reactions-in ionic nanocrystals. Science 2004, 306, (5698), 1009-1012 • Robinson, R. D.; Sadtler, B.; Demchenko, D. O.; Erdonmez, C. K.; Wang, L. W.; Alivisatos, A. P., • Spontaneous superlattice formation in nanorods through partial cation exchange. Science 2007, 317, (5836), 355-358 • IGOR L. MEDINTZ1*, H. TETSUO UYEDA2, ELLEN R. GOLDMAN1 AND HEDI MATTOUSSI, Quantum dot bioconjugates for imaging, • labelling and sensing, Nature materials 2005 • Alexander J. Mastroianni, David A. Sivak, Phillip L. Geissler, and A. Paul Alivisatos, • Probing the Conformational Distributions of Subpersistence Length DNA, Biophysical Journal 2009

More Related