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Explore essential elements and advanced techniques in searching biological databases. Understand the balance between specificity/selectivity and sensitivity in scoring schemes. Delve into gap penalties, distance/substitution matrices like PAM and BLOSUM series. Learn the significance of search parameters such as E value and bit score. Discover ways to handle data quality issues through filtering and clustering methods, and explore different algorithms like Smith-Waterman and Needleman-Wunsch for efficient searching.
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