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DSEK after Glaucoma Surgery. Safe?Effective?. Potential Problems with DSEK after Glaucoma Surgery. Donor adherence - air leaving the ACTrabeculectomy/tube failure - IOPGraft failure. . . DSEK Postops. Tube patient with previous failed PK; clear after DSEK. Bubble partially escapes day 1 through functioning trab.
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1. Descemet’s Stripping Endothelial Keratoplasty after Glaucoma Surgery Adam Easterling, M.D.
Alan Carlson, M.D.
Duke University Eye Center
ASCRS Meeting 2007
2. DSEK after Glaucoma Surgery Safe?
Effective?
3. Potential Problems with DSEK after Glaucoma Surgery Donor adherence - air leaving the AC
Trabeculectomy/tube failure - IOP
Graft failure
4. DSEK Postops
Tube patient with previous failed PK; clear after DSEK Bubble partially escapes day 1 through functioning trab
5. Our Study Retrospective chart review of first 51 patients to have DSEK at DUEC with at least one month of follow-up
Two groups:
1) 39 patients with no previous history of invasive glaucoma surgery
2) 12 patients with a trabeculectomy or glaucoma drainage device (2 trabs, 10 tubes)
6. Surgery All patients had similar surgery with a sutured limbal wound
Approximately 50% air fill in anterior chamber at the end of the case to promote donor adherence
Controls lie supine for 60 minutes
Group 2 lie supine for 60-90 minutes
7. Outcome Measures Preoperative and postoperative IOP
Number of glaucoma medications used preoperatively and postoperatively
Graft dislocation
8. Intraocular Pressure Control
9. Glaucoma Medications
10. Graft dislocation Defined as need for injection of air into the AC and/or a repeat graft for poor donor adherence
11. Discussion With regards to IOP control and donor adherence, DSEK appears to be a safe procedure after glaucoma surgery with no significant increase in the number of glaucoma drops needed
60-90 minute supine positioning is effective at promoting donor adherence
Graft dislocation is likely related to surgeon experience1, not to previous glaucoma surgery
1. Price, et al. JCRS 2006 March; 32:411-418
12. Tube/Trab patient with corneal decompensation?Consider DSEK Thanks to:
Terry Kim, M.D.
Natalie Afshari, M.D.
Felix Chau, M.D.
Sandra Stinnett, DrPH