DEVELOPING A RESEARCH PROJECT DURING RESIDENCY

1. DEVELOPING A RESEARCH PROJECT DURING RESIDENCY Mohammad Hassan Pervaiz, MD September 2005

2. OBJECTIVES To familiarize new residents with available RESEARCH RESOURCES To identify key steps for research PROJECT DEVELOPMENT "Every path to a new understanding begins in confusion."Mason Cooley

3. systematic investigation to establish facts “Research” is an active, diligent and systematic process of inquiry in order to discover, interpret or revise facts, events, behaviors, or theories, or to make practical applications with the help of such facts, laws or theories. WHAT IS “RESEARCH” inquire into

4. Which ones are for residents ?? TYPES OF MEDICAL RESEARCH • Clinical Research a-Retrospective (chart review) b-Prospective c-Meta-Analysis d-Clinical Trials e-Epidemiological Research f- Health services/ Policy analysis • Basic Science a-Animal research b-Non-animal research

5. RESOURCES PEOPLE • RESIDENT RESEARCH COORDINATOR • MSU/ SPARROW FACULTY

6. FACULTY INTERESTS • DEPARTMENT OF MEDICINE FACULTY • OTHER MSU FACULTY • NON-MSU FACULTY • OUT-OF-TOWN FACULTY

7. Dr. George Abela Chief, Cardiology Thrombosis, plaque rupture, platelet aggregation, vascular injury Dr. Barbara Conley Chief, Heme/Onc Cancer drug development; Pancreatic, head and neck cancer; molecular markers for cancer Dr. Ved Gossain Chief, Endocrinology Diabetes, obesity, thyroid and growth hormone disorders Dr. Daniel Havlichek Chief, Infectious Diseases HIV and Hepatitis Dr. Gary Ferenchick Chief, General Medicine Medical student education, information technology Dr. John Penner Chief, Thrombosis Thrombosis and homeostasis, hemophilia Dr. Ken Rosenman Chief, Occupational Medicine Disease from chemicals, heavy metals and mineral dusts Dr. John Gerlach Chief, Immunology & Serology Immunogenetics of human, transplant immunology, transfusion medicine FACULTY INTERESTS

8. Dr. Mary Nettleman, chair epidemiologic and health outcomes research Dr. Davoren Chick, Program Director healthcare services and healthcare quality, COPD FACULTY INTERESTS INTERNAL MEDICINE

9. Dr. Francesca Dwamena using the principles of effective doctor-patient relationships to understand and manage patients' symptoms Dr. Rey Bouknight health services and outcomes research for minority and poor populations especially in the areas of diabetes and cancer; healthcare quality for IM clinic Dr. Heather Laird-Fick graduate and undergraduate medical education, health care quality and disparities

10. Dr. Robert Smith doctor-patient communications and relationships, medically unexplained symptoms, somatization, teaching patient-centered interviewing, and other psychosocial principles Dr. Ade Olomu translating research into practice in the area of improving secondary prevention of myocardial infarction. Dr. Asad Mohmand Undergraduate medical education

11. Dr. Aron Sousa electronic medical record to teach students and residents how to use population health skills and techniques in their own practices Dr. Michael Zaroukian medical education, information technology and informatics, internal medicine curriculum development, and web-based education and evaluation systems in medical education. Dr. Ralph Watson basic and clinical research in hypertension.

12. INSTITUTIONAL REVIEW BOARD • UCRIHS is an Institutional Review Board (IRB) UNIVERSITY COMMISION ON RESEARCH INVLOVING HUMAN SUBJECTS Federal and University regulations require that all research projects involving human subjects and materials of human origin be reviewed and approved by an IRB before initiation

13. UCHRIS Under the regulations, all investigators (faculty &/or graduate students) who will conduct research that involves human subjects or materials of human origin (blood or tissue samples taken from live humans) must submit an application to UCRIHS Approval of the research protocol must be in place before the investigator begins data collection. IRB Reliance is an agreement between MSU and Sparrow Hospital which allows an investigator to have a research protocol undergo IRB review through UCRIHS, and Sparrow will accept the review of the lead institution

14. UCRIHS • Peter Vasilenko, Ph.D., Chair 202 Olds Hall, Michigan State UniversityEast Lansing, MI 48824-1047Phone: (517) 355-2180Fax: (517) 432-4503 E-mail: ucrihs@msu.edu http://www.humanresearch.msu.edu

15. HIPAA The Health Insurance Portability and Accountability Act UCRIHS reviews HIPAA related research protocols at the same time as the regular UCRIHS review

16. DEVELOPING YOUR OWN PROJECT • SELECT YOUR AREA OF INTEREST • SELECT A RESEARCH MENTOR • FORMULATE A RESEARCH QUESTION • COLLECT BACKGROUND INFORMATION AND DEVELOP A HYPOTHESIS • DEVELOP A PROJECT PROTOCOL • APPLY TO IRB (UCRIHS) • START PROJECT AFTER IRB APPROVAL • INTERPRET AND ANALYZE COLLECTED DATA • FUTURE PLANS (may include one or more of following) ~ Dissemination of results (presentation, publication, etc) ~ Further data collection ~ Grant submission

17. IRB REQUIREMENTS FOR RESEARCH PROTOCOL • RESEARCH STATEMENT • ABSTRACT • PROJECT DESCRIPTION ~ STUDY DESIGN ~ SAMPLE SIZE JUSTIFICATION ~ STATISTICAL ANALYSIS ~ BACKGROUND INFORMATION ~ REFRENCES • CONSENT PROCESS • HIPAA

18. “EMR” • COMPUTERIZED DATABASE • AVAILABLE ONLINE • EXCELLENT RESOURCE FOR EFFICIENT DATA EXTRACTION • CONTACT DR. ZAROUKIAN • IMPORTANT TO INFORM DR.ZAROUKIAN EARLY DURING RESEARCH DESIGN DEVELOPMENT • CONTACT DRS. BOUKNIGHT AND/OR DR.LAIRD-FICK IF INTERESTED IN CLINIC QUALITY ASSESEMENT STUDIES USING EMR. • WEB: http://www.emr.msu.edu

19. RESOURCES FOR STATISTICS • MSU INTERNAL MEDICNE FACULTY • MSU CENTER FOR STATISTICAL TRAINING AND CONSULTING: (CSTAT) • CSTAT can provide consulting on • Research design/experiments/surveys • Selection of appropriate statistical methods • Selection of statistical software • Statistical analyses • Interpretation of results • Presentation of results • Referrals • CONTACT: www.cstat.msu.edu

20. Web: http://www.im.msu.edu/program/research3.htm MSU RESEARCH ELECTIVE • 2 blocks of research time allowed • all paperwork to be submitted at least 6 weeks prior to the start of elective. • A letter from you stating your desire to do a research rotation or continuity experience. Letter must identify: • Your research mentor • The research topic • Outline of the research plan • Expected product of research experience (e.g. paper or poster) • A letter from your research mentor. In the letter it must be stated that the mentor has agreed to work with you and the letter specifies: • Research topic • Research plan • Any patient contact during the research rotation. • Agreement to evaluate you at the end of the rotation using our form. • If you are requesting a weekly research experience spanning several months, your research mentor must agree to fill out an evaluation each quarter that you are involved in the weekly research experience.

21. SUMMARY • Go to available MSU web links to learn about the resources in greater details • Familiarize yourself with the research interests of the appropriate faculty researcher before approaching them • Ask Dr.Dwamena for help ! • Start Early! • "I know quite certainly that I have no special gift. Curiosity, obsession and dogged endurance have brought me my ideas."Albert Einstein

22. IMPORTANT WEB-LINKS • MSU IM ~ Research http://im.msu.edu/program/research3.htm • UCRIHShttp://www.humanresearch.msu.edu/ • SPARROW IRBhttp://www.sparrow.org/irrc/irrc_aboutirrc.asp • CSTATwww.cstat.msu.edu • MSU INTRAMURAL RESEARCH GRANThttps://www.vprgs.msu.edu • CHM ~ Researchhttp://humanmedicine.msu.edu/research/ • HEALTH TEAM ~ Researchhttp://www.healthteam.msu.edu/medicine/research.htm

23. QUESTIONS !