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Smallpox Vaccine Adverse Events Guidance for Clinicians - Key Points Review

This teaching set provides guidance on expected smallpox vaccine reactions, including normal and major reactions for first-time vaccinees and revaccinees. Learn about rates of expected reactions, common symptoms, and satellite lesions. Understand vaccination site reactions like fatigue, headache, myalgia, and more.

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Smallpox Vaccine Adverse Events Guidance for Clinicians - Key Points Review

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Presentation Transcript

  1. Smallpox Vaccine Adverse EventsPublic Health Guidance for Clinicians A Teaching Set Reviewing Key Points in the MMWR Report

  2. Expected Vaccination Site Reaction

  3. Normal ReactionDay 7

  4. Normal ReactionDay 12

  5. Major ReactionFirst time vaccinee, Day 6

  6. Major ReactionFirst time vaccinee, Day 10

  7. Major ReactionFirst time vaccinee, Day 15

  8. Major ReactionRevaccinee, Day 4

  9. Major ReactionRevaccinee, Day 8

  10. Major ReactionRevaccinee, Day 10

  11. Major ReactionRevaccinee, Day 15

  12. Expected Range of Vaccine Reactions • Fatigue • Headache • Myalgia • Lymphadenopathy • Lymphangitis • Pruritis • Edema at the vaccination site • Satellite Lesions

  13. Rates of Expected Reactions • 21% complications required physician consult • Most Common Symptoms • Fatigue (50%) • Headache (40%) • Muscle aches and Chills (20%) • Nausea (20%) • Fever  37.7 ºC or 100 ºF (10%)

  14. Satellite LesionsNaïve Patient, Day 7

  15. Satellite Lesions

  16. Large Vaccination Reactions and Robust TakesRobust take with lymphangitis

  17. Large Vaccination Reactions and Robust TakesRobust take with lymphangitis

  18. Large Vaccination Reactions and Robust TakesLarge Local Reaction

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