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Malabsorption

Malabsorption. De Vera, Jestha Marie Bernadette Dela Cruz, Ciara Mae Dela Cruz, Fatima. Malabsorption. Defective absorption of fats, fat-soluble and other vitamins, proteins, carbohydrates, electrolytes and minerals, and water Most common clinical presentation is CHRONIC DIARRHEA

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Malabsorption

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  1. Malabsorption De Vera, Jestha Marie Bernadette Dela Cruz, Ciara Mae Dela Cruz, Fatima

  2. Malabsorption • Defective absorption of fats, fat-soluble and other vitamins, proteins, carbohydrates, electrolytes and minerals, and water • Most common clinical presentation is CHRONIC DIARRHEA • Hallmark: Steatorrhea • Cause excessive fecal excretion and produce nutritional deficiencies and GI symptoms

  3. Malabsorption occurs when any of these digestive functions is impaired: • INTRALUMINAL DIGESTION • Proteins, carbohydrates and fats are broken-down into assimilable forms. • TERMINAL DIGESTION • Hydrolysis of carbohydrates and peptides in the brush border of the small intestinal mucosa • TRANSEPITHELIAL TRANSPORT • Nutrients, fluid & electrolytes are transported across the epithelium of the small intestine for delivery to the intestinal vasculature • Absorbed fatty acids  triglycerides + cholesterol  chylomicrons intestinal lymphatic system

  4. COMMON CAUSES OF MALABSORPTION

  5. Work-ups Timed (72 h) quantitative stool collection • Fat malabsorption: >6g in 24 h Complete blood count Small intestinal mucosal biopsy • Short or absent villi • Mononuclear infiltrate • Epithelial cell damage • Hypertrophy of crypts

  6. Treatment Broad-spectrum antibiotics • Tetracycline for up to 6 months Folic Acid

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