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Multiple Scleroses: The Neuroscientific Paradigm

Multiple Scleroses: The Neuroscientific Paradigm. Amna Hyder, Hannah Dies, Yohan Yee, Piotr Roztocki † † Honours Integrated Science, McMaster University. Context. Multiple Sclerosis. Types of Neurons. Structure of a T ypical Neuron. Acton Potential. Action Potential. Electrodiffusion.

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Multiple Scleroses: The Neuroscientific Paradigm

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  1. Multiple Scleroses: The Neuroscientific Paradigm Amna Hyder, Hannah Dies, Yohan Yee, Piotr Roztocki† †Honours Integrated Science, McMaster University

  2. Context

  3. Multiple Sclerosis

  4. Types of Neurons

  5. Structure of a Typical Neuron

  6. Acton Potential

  7. Action Potential

  8. Electrodiffusion

  9. Circuits

  10. Dendrite

  11. Potential and Current – exponential decay

  12. Capacitance • C = (Charge) / (Voltage) = Q/V • HIGH capacitance: • More ions are required to charge the membrane • Reduces the distance at which the current propagates • Want LOWER capacitance!

  13. Myelination – Multiple Sclerosis

  14. Information Transfer

  15. Spike Train

  16. MS Symptoms

  17. Normal Immune system

  18. Blood brain barrier break down • biomarkers • T-cell attack • molecular mimicry • virus cause?

  19. MS Symptoms

  20. Scleroses (Plaques)

  21. Diagnosis

  22. Spinal Fluid Examination

  23. Neurological Tests

  24. MRI

  25. Coherence induced by resonance

  26. Diffusion MRI

  27. Treatment Common: • Corticosteroids • Interferon-β Emerging Treatments: • Remyelination • CCSVI Surgery

  28. Epidemiology Evidence for: • Infection-related Factors • Genetic Factors • Environmental Factors

  29. Integrated Science

  30. Science FairQuestions?Comments?

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