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Today

Today. Elements of complex genomes Protein domains and exon shuffling Origin of novel genes Alternative splicing Transposable elements and genome size. Protein domains bind antigens in human immunoglobulin. Evolution and conservation of domains in diverse proteins.

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Today

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  1. Today • Elements of complex genomes • Protein domains and exon shuffling • Origin of novel genes • Alternative splicing • Transposable elements and genome size

  2. Protein domains bind antigens in human immunoglobulin

  3. Evolution and conservation of domains in diverse proteins

  4. New domains and human cognition

  5. Number of paralogs in complete genomes of five species of yeast

  6. Paralog number and organismal complexity

  7. Origin of a new Drosophila gene, jingwei

  8. Antarctic Notothenoids - a radiation of ‘ice fish’

  9. The evolution of AFGP genes of Antarctic notothenioid fishes

  10. Mechanisms of creating new genes

  11. Co-option of an ancient transposable element

  12. Abundance of an novel transposable element in coelacanth

  13. Identifying cases of alternative splicing Tall boxes - human Short boxes - mouse Genomic sequence (introns and exons) Shading indicates matches of genomic sequence and ESTs (white - 1 or 2 database matches; dark - multiple database matches)

  14. Drosophila Dscam gene

  15. Alterantive splicing in the Drosophila fruitless gene

  16. Splice variants control sexual behavior • fruF prevents male-specific splicing • fruM and fru∆tra force male splicing • FruC, control allele

  17. The ENCODE project and new view of the gene Mark B. Gerstein et al. Genome Res. 2007; 17: 669-681

  18. Genome size variation

  19. Fractions of genomic DNA

  20. Age distribution of human retroelements

  21. Small genomes Little repetitive DNA Small introns (?) Michrochomosomes High gene density Large genomes Abundant repeats Large introns Macrochromosomes Low gene density Classic genomic differences between birds and mammals

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