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Rhinovirus

Rhinovirus. a.k.a. the common cold virus. The Stats. one of the most common illnesses to man leading cause of doctor visits and lost hours both at school and the workplace over 200 different viruses found to cause symptoms of the common cold

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Rhinovirus

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  1. Rhinovirus a.k.a. the common cold virus

  2. The Stats • one of the most common illnesses to man • leading cause of doctor visits and lost hours both at school and the workplace • over 200 different viruses found to cause symptoms of the common cold • responsible for about 70% of the cases where a virus has been found • 35 to 50% of the total number of common colds • Hand to hand contact

  3. Normal Cells Infected Cells

  4. Rhinovirus 14 • Rhinovirus 14 as colored by proteins • VP1- blue • VP2- green • VP3- red • VP4- yellow, inside

  5. Structure

  6. Topography of Rhinovirus 14

  7. ►20 faces contain 5 fold vertices ►Each facet is divided into 60 triangles ►Each contains one of the following: VP1, VP2, VP3 (VP4 is found on the inside) -VP1 proteins form a protrusion at the 5 fold axis -around this protrusion is a depression know as the ‘canyon’ -the canyon is where cell receptors bond to the virus

  8. Rhinovirus • Picornoviridae family • Size • Single stranded • Incubation period of 1 to 3 days • Optimum growth occurs between 33 and 34 deg Celcius (93 deg F) • Not stable below the pH of 5-6

  9. Entering a Cell Rhinovirus bonded to a CAM 1 receptor Antibodies bonded to a rhinovirus

  10. Intercellular Adhesion Protein-1ICAM-1 • Receptor for most human rhinovirus serotypes • Single protein- divided into 5 sections • Shape • Adhesion molecule • ICAM-1 and white blood cells Rhinovirus 16 with ICAM-1 receptors attatched

  11. Conclusion • Purdue University- Michael G. Rossmann and colleagues have been studying the 3-D structure of ICAM-1 (intercellular adhesion molecule one) which is the port of entry for the cold virus into the human cell • Importance of X-ray Crystallography to research • Get your own from GIANT Microbeshttp://www.giantmicrobes.comhttp://www.riesenmikroben.de

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