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LD-50 Lab Introduction

LD-50 Lab Introduction. earthref.org. Scripps Classroom Connection. “Everything is poisonous yet nothing is poisonous.” Paracelsus. earthref.org. Scripps Classroom Connection. Max Benefit. Beneficial. Increasing Amount. H armful . Everything can be beneficial up

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LD-50 Lab Introduction

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  1. LD-50 Lab Introduction earthref.org Scripps Classroom Connection

  2. “Everything is poisonous yet nothing is poisonous.”Paracelsus earthref.org Scripps Classroom Connection

  3. Max Benefit Beneficial Increasing Amount Harmful Everything can be beneficial up to a certain point, and then might be harmful. • earthref.org Scripps Classroom Connection

  4. Example: Watching TV Max Benefit Beneficial 0.5 1 2 3 4 5 6 7 Increasing Hours Harmful • earthref.org Scripps Classroom Connection

  5. Dose Response Curves • How can you decide what is the optimal dose? A harmful dose? • Important dose “indicator” • LD50-lethal dose, where 50% of the population dies • earthref.org Scripps Classroom Connection

  6. A Closer Look: LD 50 Examples Toxic Substance A 100 100 Toxic Substance B 50 50 % Showing A Response 0 0 Dose of toxicant • earthref.org Scripps Classroom Connection

  7. Threshold Effects Threshold:no effects are seen to occur in response to the dose 100 Which substance, A or B has a higher threshold for toxicity? A B 50 Response % 0 • earthref.org Scripps Classroom Connection

  8. Risk Assessments • Determining potential adverse environmental health effects on people exposed to pollutants • LD50 and threshold effects • Includes many steps and processing • Eventually incorporated into regulations • earthref.org Scripps Classroom Connection

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