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544M - DIFFERENTIATION

544M - DIFFERENTIATION. HK232M - DIFFERENTIATION. GLUTAMATE. HYPOXIA. DEXAMETHASONE. IFNG. DIAZEPAM, FLUOXETINE. BETA AMYLOID, IMIPRAMINE. N-PROPYL-L-ARGININE. Expression data - 81 samples. Expression data clustered with the arrange program.

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544M - DIFFERENTIATION

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  1. 544M - DIFFERENTIATION HK232M - DIFFERENTIATION GLUTAMATE HYPOXIA DEXAMETHASONE IFNG DIAZEPAM, FLUOXETINE BETA AMYLOID, IMIPRAMINE N-PROPYL-L-ARGININE Expression data - 81 samples

  2. Expression data clustered with the arrange program

  3. Clustering samples on expression and on motifs • The samples were clustered on expression correlation using the SPC method. This gave the following results: • This can be compared to arranging the samples on similar treatments, as shown before: • The samples were also clustered on significant motifs from TransFac: AP-2 USF NF-Y NF-kappa B

  4. Significant sequences of length 4 - 7 • One iteration of REDUCE • Top 50 sequences for each sample • Red dots indicate activation • Green dots indicate repression • Motifs are clustered on the effect • Are sequences with similar effect variations of the same motif ?

  5. Same picture as before, but on all sequences with significance > 0.001 • More sequences in the heatmap • Same structure as before

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