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Spare slides. Sex Determination in humans. Chromosomes. Chromosomal sex. Regulator Genes. Genetic sex. Prenatal Hormones. Phenotypic sex. External & internal genitalia. Gonads. Genital sex. Gonadal sex. Brain structures. Brain sex. Gonads and internal genitalia. SRYgene.

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  1. Spare slides

  2. Sex Determination in humans Chromosomes Chromosomal sex Regulator Genes Genetic sex Prenatal Hormones Phenotypic sex External & internal genitalia Gonads Genital sex Gonadal sex Brain structures Brain sex

  3. Gonads and internal genitalia SRYgene Development of testes Mullerian Inhibiting Factor & others Testosterone Wollfian duct develops Müllerian Duct degenerates Epididymis Vas Deferens Seminal Vesicles Prostate Gland

  4. Male Differentiation Testosterone (from testes) Wolffian Duct develops Epididymis Vas Deferens Seminal Vesicles Prostate Gland

  5. Male Differentiation SRY gene Mullerian Inhibiting Factor & other factors Müllerian Duct degenerates

  6. Wnt-4 Gene • Essential for female development • Prevents production of testosterone • Initiates development of Mullerian duct • Necessary for proper oocyte development • Suppresses Wolffian duct

  7. Female Differentiation No Y, No SRY, No MIF Development of ovaries Wnt-4 Gene Activates Müllerian Duct Fallopian Tubes Uterus Cervix Inner vagina

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