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Biology of Influenza A

Will Avian Influenza become Human? Question : How could H5N1 become dangerous to humans? Mutation of H5 to bind to human receptors? Re-assortment by genetic shift to H1N1? Biology of Influenza A H5N1 and H1N1 ClustalW separates man from bird. http://workbench.sdsc.edu

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Biology of Influenza A

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  1. Will Avian Influenza become Human? • Question: How could H5N1 become dangerous to humans? • Mutation of H5 to bind to human receptors? • Re-assortment by genetic shift to H1N1? Biology of Influenza A H5N1 and H1N1 ClustalW separates man from bird. http://workbench.sdsc.edu http://www.vetscite.org/publish/articles/000041/img0002.jpg From PDB Molecule of the Month • H (16 types)N (9types) designation • H types that infect humans 1, 2, 3 • H types that infect birds: 3, 4, 6 (freq) 5,7 less common • Bird Flu=H5N1 http://www.ebi.ac.uk/interpro/potm/2006_4/Page1.htm Ab covering HA Genetic shift vs. drift A/Thailand/1[KAN-1A]/2004[H CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/Vietnam/PEV16T/2005[H5N1] CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVMWGIHHPNDA A/chicken/Thailand/Kanchana CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/chicken/Thailand/Nontabur CPYQGKSSFFRNVVWLIKKNSTYPIIKRSYNNTNQEDLLVLWGIHHPNDA A/quail/Thailand/Nakhon_Pat CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/goldeneye_duck/Bavaria/19/ CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/tufted_duck/Bavaria/9/2006 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/swan/Bavaria/16/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/swan/Bavaria/6/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/buzzard/Bavaria/5/2006[H5N CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/tufted_duck/Bavaria/8/2006 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/swan/Bavaria/17/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/swan/Bavaria/21/2006[H5N1 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/teal/Egypt/14051-NAMRU3/2 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/goosander/Switzerland/V82/ CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/chicken/Egypt/10845-NAMRU CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA A/goose/Guangzhou/471/2006[ CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDA A/China/GD01/2006[H5N1] CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNNA A/Owston's_civet/Vietnam/1/2 CPYQGNSSFFRNVVWLIKKNDAYPTIKRSYNNTNQEDLLVLWGIHHPNDE A/Indonesia/CDC887/2006[H5N CPYLRSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNNE A/Indonesia/CDC836T/2006[H5 CPYLGSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNDA A/teal/Egypt/9885-NAMRU3/20 CPYNGRSSFFRNVVWLIKKNNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA *** .************:.:** **:***********::*****.*: A/Thailand/1[KAN-1A]/2004[H AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSEVNGQSGRMEFFWTILK A/Vietnam/PEV16T/2005[H5N1] AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK A/chicken/Thailand/Kanchana AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK A/chicken/Thailand/Nontabur AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK A/quail/Thailand/Nakhon_Pat AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRPKVNGQSGRMEFFWTILK A/goldeneye_duck/Bavaria/19/ AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/tufted_duck/Bavaria/9/2006 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/swan/Bavaria/16/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/swan/Bavaria/6/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/buzzard/Bavaria/5/2006[H5N AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/tufted_duck/Bavaria/8/2006 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/swan/Bavaria/17/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/swan/Bavaria/21/2006[H5N1 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/teal/Egypt/14051-NAMRU3/2 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/goosander/Switzerland/V82/ AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/chicken/Egypt/10845-NAMRU AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/goose/Guangzhou/471/2006[ AEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILK A/China/GD01/2006[H5N1] AEQTKLYQNPTTYISVGTSTLNLRLVPKIATRSKVNGQSGRMDFFWTILK A/Owston's_civet/Vietnam/1/2 AEQTRLYQNPTTYVSIGTSTLNQRLVPKIATRSKVNGQSGRIDFFWTILK A/Indonesia/CDC887/2006[H5N AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK A/Indonesia/CDC836T/2006[H5 AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWAILK A/teal/Egypt/9885-NAMRU3/20 AEQTKLYQNPTTYVSVGTSLLNQRSVPEIATRPKVNGQSGRMEFFWTILK ****:********:*:*** ** * **.****.:*******::***:***

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