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USC Addiction and Violence Research Center

USC Addiction and Violence Research Center. Jean C. Shih, Ph.D. School of Pharmacy University of Southern California. The First Structure of MAOB (Nat. Struc. Bol. 2002). MAO A- inhibitor interaction . MAO B Gene Regulation. Stress Inflammatory cytokines growth factors. PMA.

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USC Addiction and Violence Research Center

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  1. USC Addiction and Violence Research Center Jean C. Shih, Ph.D. School of Pharmacy University of Southern California

  2. The First Structure of MAOB(Nat. Struc. Bol. 2002)

  3. MAO A- inhibitor interaction

  4. MAO B Gene Regulation Stress Inflammatory cytokines growth factors PMA Growth factors mitogens PKC cytoplasm MAPK Pathway nucleus Egr-1 c-Jun Sp3 Sp3 / BTEB2 TIEG2 MAO B Gene TATA CACCC Sp1 / Sp4

  5. MAO B KO mice Wild type mice MAO A/B double KO mice MAO A KO mice

  6. Forebrain-specific transgenic MAO A KO mice 5-HT, NE, DA normal level in forebrain No aggression MAO B KO mice PEA  No aggression MAO A/B double KO mice 5-HT, NE, DA   PEA   Anxiety Disregulation of heart rate MAO A KO mice 5-HT, NE, DA  aggression Different levels of 5-HT lead to different signaling pathways which lead to different behaviors The increased 5-HT in forebrain is responsible for aggression

  7. USC Addiction and Violence Research Center For Studying the Cause, Treatment and Prevention of Drug Abuse and Violence Addiction and Violence: Clinical Studies *Psychological traits *Psychiatric diagnosis (addiction, depression anxiety, aggression) D. Holschneider, J. Victoroff USC Keck School of Medicine Addiction: Social Studies Using 10,000 methamphetamine abusers *Demographics (gender, twins, ethnicity, type of substance, criminal justice status) *Social factors (employment and environmental stressors) *Developmental factors (childhood development, maternal smoking and substance use) Y. Hser, UCLA Neuro-imaging A. Raine and others USC College of Letters, Arts and Sciences, Psychology Bioinformatics D. Conti USC Keck School of Medicine Animal Models (transgenic mice) Metabolome (correlate brain and urine levels) Behavior K. Chen, USC School of Pharmacy D. Holschneider, USC Keck School of Medicine DNA, SNP Mutation Discovery (Genes in serotonin and dopamine pathways) J. Shih, K. Chen, USC School of Pharmacy D. Conti, USC Keck School of Medicine L. Baker,USC College of Letters, Arts & Sciences, Psychology Education J. Colbert, M. Sundt, USC School of Education R. Aster, USC School of Social Worker

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