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(2) ENERGY PRODUCTION IN EXERCISE KUORMITUKSESSA. Immediate energy stores Anaerobic glykolysis Aerobic energy production. IMMEDIATE ENERGY STORES. = Hi-energy phosphates adenocine-triphosphate (ATP) and creatinephosphate (CP) – stores.
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(2) ENERGY PRODUCTION IN EXERCISE KUORMITUKSESSA
Immediateenergystores • Anaerobicglykolysis • Aerobic energyproduction
IMMEDIATE ENERGY STORES = Hi-energyphosphatesadenocine-triphosphate (ATP) and creatinephosphate (CP) –stores ATP: storage in cells 80-100 g (in musclesabout 50%, enough for max. work of 2-3 s ) CP (PCr): stores 4-6 x that of ATP-stores (sufficient for maximalwork for 10 s ) -reactionsdon’treguireoxygen
Creatineloading (creatiinimonohydrate, CrH2O) hasbeenshown to enhanceperformance in shortmaximalbouts, addsalsobodyweight
Maximalbouts of action: 1. Under 30 s ATP ja KP 2. 30s – 1½ min ATP, CP ja anaero- bicglykolysis 3. 1½-3 min Anaer. ja aer. glykol. 4. Over 3 min Aerobic energyproduction
ANAEROBIC GLYCOLYSIS • Glucose/glycogen→ pyruvicacid→lacticacid • - no oxygenneeded (anaerobic) • 10 steps • occurs in watery medium of cell • only2/3 molecules of ATP is formed/glucose/glycogenmolecule,alsohydrogen is produced to electrontransferchain • activity of glycolysisdepends on the amount/activity of regulatoryenzymes, amount of oxygen and availability of glucose • end-productis pyruvicacidwhich is sent to aerobic processKrebscycle • some of the pyruvicacid is turned into lacticacid
Glucose from blood into cell • breakdown of muscle glycogen more economical (net result 3 ATP molecules) 2 ATP:tä kuluu - FT-cells contain more PCK (most important regulatory enzyme) In very heavy work all 6 hydrogen ions cannot be transformed with oxygen in electron transfer chain - acidosis
Lacticacid is split into lactate and hydrogenions • Lactate is moved into bloodstream • even at restthere is somelactate in blood (redbloodcells and FT-cells) • used in energyproduction in muscles,especiallyheart • gluconeogenesis (Coricycle in liver) transformslactate into glucosewhenenoughoxygen is available in lesspowerfulwork
On the otherhand: • lactate is produced in musclesevenwhenthere is no lack of oxygen • lactate is alsoproduced in liver,skin and heart • lactate is the mostimportantenergysource of heart in heavy work
use of immediate energy sources and anaerobic glycolysis are parallel energy sources • lactate starts to accumulate in working muscles before hi-energy phosphates are fully used
transfer of lactate from blood is fastest at work rates of 30-45 % VO2max in cycle ergometer work • on treadmill power should be 55-60 % VO2max
muscular exhaustion is not equal to amount of lactate in muscle • - Lactate accumulation and lowering of muscle pH both play a role in muscular exhaustion • diminishing muscle glycogen stores and hi-energy phosphates are also important factors in exhaustion • other apparent reasons are at central nervous system level and in neuromuscular junctions