Table 1: Transmissible spongiform encephalopathies

Table 1: Transmissible spongiform encephalopathies

Table2: Human transmissible spongiform encephalopathies BSE: bovine spongiform encephalopathy; CJD: Creutzfeldt-Jakob disease; FFI: fatal familial insomnia; GSS: Gerstmann-Straussler-Scheinker-syndrome; PRNP: prion protein gene; vCJD: variant Creutzfeldt-Jakob disease

Table 3: Normal and abnormal forms of the prion protein (PRP)

Figure 1: Spongiform change in Creutzfeldt-Jakob diseases (CJD) consisting of vacuoles within neuronal cell.

Figure 2: Astrocytosis in CJD

Figure 3: Amyloid plaques as a result of prion protein (PrP) immunostaining.

Figure 4: Incidence of BSE in Great Britain

Figure 5: Estimated number of infected animals slaughtered for human consumption in both Republic of Ireland and Northern Ireland

Figure 6: Incidence of CJD in Great Britain

Figure 8: Hockey-stick sign of vCJD on FLAIR image Figure 7: Pulvinar sign of vCJD on T2 -weighted image

Figure 9: Pulvinar sign of vCJD on FLAIR image

Table 4: World Health Organization Case Definition for vCJD : Depression, anxiety, apathy, withdrawal, delusions : Frank pain and/or dysthesia : Generalized triphasic periodic complexes at approximately one per second : Relative to the signal intensity of the other deep gray matter nuclei and cortical gray matter : Spongiform change and extensive PrP deposition with florid plaques throughout the cerebrum and cerebellum.

Table 1: Transmissible spongiform encephalopathies