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The Dr. John T. Macdonald Foundation

The Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute at the University of Miami ( BioNIUM ). Richard J. Cote, M.D., FRCPath , FCAP, Director Ram H. Datar, M.Phil , Ph.D., Co-Director Sylvia Daunert , Ph.D., Pharm.D ., Associate Director. BioNIUM Mission and Vision.

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The Dr. John T. Macdonald Foundation

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  1. The Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute at the University of Miami (BioNIUM) Richard J. Cote, M.D., FRCPath, FCAP, Director Ram H. Datar, M.Phil, Ph.D., Co-Director Sylvia Daunert, Ph.D., Pharm.D., Associate Director

  2. BioNIUM Mission and Vision • Mission: • Early detection and diagnosis • Targeted delivery and treatment monitoring • Restoration of tissue and organ function • Vision: • Multidisciplinary collaboration and technology development • Integrate nanotechnology and medicine to: • Develop and deploy devices and systems • Interact with living tissue • Provide size and physical property advantages • Educating the next generation of physicians, scientists and engineers

  3. Overcoming Significant Barriers to Early Effective Treatment Cancer: • Early detection of circulating tumor cells • Insensitive and expensive detection of serum biomarkers • Adverse drug effect on non-targeted cells and organs Endocrine and Cardiac Diseases: • Inability to continuously monitor glucose or cardiac enzymes • Restore lost function Neuromuscular Diseases: • Once disease is treated, full restoration remains distant goal • Interdisciplinary Collaboration: Physicians, Biomedical Researchers, Physicists, Chemists, Engineers, Material Scientists • Link researchers from disparate disciplines to expand scientific knowledge • Opportunities to exchange and expand novel ideas

  4. BioNIUM Members: Multidisciplinary Leaders Converge • Richard J. Cote, M.D., professor and Joseph R. Coulter Jr. Chair of Pathology • Ram Datar, M.Phil., Ph.D., associate professor of pathology and biochemistry and molecular biology • Sylvia Daunert, Ph.D., Pharm.D., professor and the Lucille P. Markey Chair of Biochemistry and Molecular Biology • James M. Tien, Ph.D., DEng, NAE, dean School of Engineering • Richard Awdeh, M.D., assistant professor of clinical ophthalmology, Bascom Palmer Eye Institute • Leonidas Bachas, Ph.D., dean College of Arts and Sciences • PirouzDaftarian, Ph.D., research assistant professor of microbiology and immunology • SapnaDeo, Ph.D., associate professor of biochemistry and molecular biology • Jeffrey Goldberg, M.D., Ph.D., associate professor of ophthalmology • Angel Kaifer, Ph.D., professor of chemistry • Sung Jin Kim, Ph.D., assistant professor of electrical and computer engineering • Vincent Moy, Ph.D., associate professor of physiology and biophysics • Francisco Raymo, Ph.D., professor of chemistry • Paolo Serafini, Ph.D., research assistant professor of microbiology and immunology • Cherie Stabler, Ph.D., assistant professor of biomedical engineering and director of the tissue engineering program at the Diabetes Research Institute • OnurTigli, Ph.D., assistant professor of electrical and computer engineering

  5. Dr. John T. Macdonald FoundationPropelling BioNIUM Forward • A leadership contribution of $7.5 million over five years will provide crucial support to: • Recruit leading experts • Equip and operate a state-of-the-art microfabrication and nanofabrication core facility • Launch ‘high risk-high yield’ pilot research projects • Educate the next generation of physicians, biomedical scientists and engineers • Support scientific leadership and oversight, and create scientific advisory boards • University of Miami has committed additional funds of $4.8 million • Provost - $2.8 Million • Dean of the Miller School- $1 Million • Dean of the College of Engineering- $1 Million • Return on Investment: This grant will stimulate creation of over 85 new highly skilled jobs in Miami-Dade County and result in over $100M in research funding.

  6. Progress with Nanofab Clean Room • Nanofabrication facility clean room space identified in Life Science & Technology Park, 1st floor • A 1200 Sq. Ft. Space within the Tissue & Bone Bank • Equipment orders will begin shortly • Support Staff recruitment planned for Fall of 2012 • Facility Business Plan ready

  7. Opportunities • The combination of recent and ongoing recruitments presents an ideal moment for the establishment of the Dr. John T. Macdonald Foundation BioNIUM. • The resources provided by the Dr. John T. Macdonald Foundation gift establish major programmatic support, enhance recruitment efforts and allow for the build out of critical infrastructure (nano/micro fabrication clean room facility). • With a critical mass of human and technological resources, the BioNIUM will facilitate interdisciplinary collaborations that will accelerate the pace of discovery.

  8. Organizational Overview • Led by a Director: Responsible for articulating and representing the vision of the Institute, its overall leadership and management. • The Director will report to and receive annual reviews from the Senior Vice President for Medical Affairs and Dean of the Miller School. • Executive Committee: Advise the Director on issues related to Institute operations. • Advisory Committee: Assess the scientific progress of the Institute and assist the Director in long term planning. • Advisory Board: Representation from UM and the Dr. JT Macdonald Foundation. Provide insight and recommendations • Four Scientific Programs (led by Program Directors) and two Shared Resources (led by Resource Directors).

  9. BioNIUM Programs & BioNIUM Resources • Programs • Sensing & Molecular Diagnostics • Molecular Assemblies and Characterization of Nanostructures • Functional Restoration and Biomaterials • Targeting, Delivery and Imaging Using Nanocarriers • Resources • Nanofabrication Facility • Interdisciplinary Educational Resource

  10. Space Research activities of the Dr. John T. Macdonald Foundation BioNIUM require a well-equipped fabrication facility, and office and administrative space. • Initially the main offices of the Institute will reside in the Biomedical Research Building on the Miller Campus • The state-of-the-art nanofabrication facility will be located at the Life Science and Technology Park. • Through its affiliate membership laboratories, the Institute will have space on the Coral Gables and Miller School campuses.

  11. Co-Director BioNIUM Organizational Chart Senior Vice President for Medical Affairs & Dean Advisory Board Executive Committee Advisory Committee Director, Dr. John T. Macdonald FoundationBioNIUM Associate Director Program Director, Sensing & Molecular Diagnostics Program Director, Molecular Assemblies & Characterization of Nanostructures Program Director, Functional Restoration Program Director, Biomaterials, & Targeting, Delivery and Imaging Using Nanocarriers Resource Director, Nanofabrication Facility & Resource Director, Educational Resources

  12. BioNano Medicine: The Final Frontier– Science Fiction? Now a reality!

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