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Necrosis

Necrosis. Tammy Do Trauma Research Associates Program 8.24.2012. Necrosis. Premature death of cells/death of body tissue Apoptosis vs. Necrosis Caused by: Infections Toxins Trauma Ischemia. Causes. Ischemia Thrombosis/embolism Infection/Disease Fungal/bacterial Diabetes

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Necrosis

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  1. Necrosis Tammy Do Trauma Research Associates Program 8.24.2012

  2. Necrosis • Premature death of cells/death of body tissue • Apoptosis vs. Necrosis • Caused by: • Infections • Toxins • Trauma • Ischemia

  3. Causes • Ischemia • Thrombosis/embolism • Infection/Disease • Fungal/bacterial • Diabetes • Chemicals • Poisons/toxins • venom • Trauma

  4. Necrotic Wound from Spider Bite

  5. Types of Necrosis • Coagulative • Liquefactive • Caseous • Fatty • Fibrinoid • Gangrenous • Aseptic

  6. Coagulative Necrosis • Caused by ischemia • Denaturation of structural proteins • Enzymatic digestion of cells • Architecture of tissue preserved • Occurs in organs like heart, spleen, kidney • Does not occur in brain

  7. Liquefactive Necrosis • Necrotic tissue digested by enzymes into liquid • Associated with abscess formation • Commonly seen in brain • ischemia • Fungal or bacterial infection • Not in brain

  8. Caseous Necrosis • Necrotic tissue is crumbly and cheese-like • Typically caused by tuberculosis • Syphilis • fungal

  9. Fat Necrosis • In response to trauma • Lipases break down fats • React with calcium: saponification • Chalky white deposits • Most commonly seen in pancreas and breasts • Acute pancreatitis

  10. Fibrinoid Necrosis • Caused by deposition of fibrin or fibrin-like materials • Vasculitis

  11. Gangrenous Necrosis • Considerable mass of necrosis • Types of gangrene • Dry • Wet • Gas • Dry Necrosis • Form of coagulative • Caused by ischemia • Autoamputation • Distal parts of limbs • Dry, shrunken, black

  12. Gangrenous Cont. • Wet • Moist tissue and organs • Characterized by bacterial infection • Dark, swollen, foul odor • Gas • Bacterial infection that produces gas within tissue • Deadly

  13. Gangrenous Cont.

  14. Aseptic Necrosis • Avascular necrosis or osteonecrosis • Necrosis of bone • Lack of blood supply to bone • Medications, trauma, ischemia, hypercoagulable blood, alcoholism

  15. Treatment • Depends on the extent of damage • Restoration of blood flow • Maggot Therapy • Debridement • Amputation

  16. Sources • http://onlinemedicinefacts.com/pathology/caseous-necrosis-liquefactive-necrosis-and-fibrinoid-necrosis • http://www.symptomsbook.com/Facts-Therapy-Pictures-Diagnosed-Information-Diagnosis-Herceptin-Treated-necrosis-Diagnosed-Diagnosis.htm • http://www.medicinenet.com/aseptic_necrosis/article.htm • http://www.nlm.nih.gov/medlineplus/ency/article/002266.htm • http://www.mayoclinic.com/health/avascular-necrosis/DS00650 • http://library.med.utah.edu/WebPath/CINJHTML/CINJ029.html

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